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What is Dobutrex
DobutamineThe Generic name of this drug
Treatment SummaryDobutamine is a drug used to increase the strength of heart contractions, making it useful for treating heart conditions such as after a heart attack or open heart surgery. It works by stimulating the beta-1 receptors in the heart without causing an increase in heart rate or narrowing of the blood vessels.
Dobutamine Hydrochloride in Dextroseis the brand name
Dobutrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dobutamine Hydrochloride in Dextrose
Dobutamine
1993
22
Approved as Treatment by the FDA
Dobutamine, otherwise called Dobutamine Hydrochloride in Dextrose, is approved by the FDA for 2 uses like Cardiac Decompensation and Heart Failure .Cardiac Decompensation
Helps manage Cardiac Decompensation
Heart Failure
Helps manage Cardiac Decompensation
Effectiveness
How Dobutrex Affects PatientsDobutamine is a drug that strengthens the heart and increases its ability to pump blood. It works by activating the beta-1 adrenergic receptors in the heart, but has only small effects on other types of receptors. Unlike dopamine, it does not cause the body to produce more norepinephrine.
How Dobutrex works in the bodyDobutamine helps the heart pump more blood by stimulating the beta-1 receptors in the heart. This increases the amount of blood the heart pumps out, resulting in a greater cardiac output.
When to interrupt dosage
The quantity of Dobutrex is contingent upon the identified disorder, including Heart Attack, Cardiac Surgical Procedures (D006348) and Coronary Artery Disease (CAD). The amount of dosage is contingent upon the technique of delivery (e.g. Intravenous or Liquid - Intravenous) specified in the following table.Condition
Dosage
Administration
Heart Failure
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Coronary Disease
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Heart Attack
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Cardiac Surgical Procedures (D006348)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Therapeutic procedure
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Stress Echocardiography (SE)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Warnings
Dobutrex has one contraindication, and should not be utilized if any of the conditions in the following table are present.Dobutrex ContraindicationsCondition
Risk Level
Notes
Cardiomyopathy, Hypertrophic
Do Not Combine
Common Dobutrex Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Dobutamine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
1-benzylimidazole
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Dobutrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Dobutrex?
63 active studies are presently investigating the potential of Dobutrex to effectuate Therapeutic procedure, Cardiac Decompensation and Myocardial Infarction.Condition
Clinical Trials
Trial Phases
Heart Failure
0 Actively Recruiting
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Stress Echocardiography (SE)
0 Actively Recruiting
Coronary Disease
1 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting
Cardiac Surgical Procedures (D006348)
0 Actively Recruiting
Dobutrex Reviews: What are patients saying about Dobutrex?
2.7Patient Review
3/16/20091Patient Review
10/5/2010 We had to convince the medical staff multiple times to stop giving this medication to our son while he was in the ICU. Every time they administered it, his vitals would drop and everything would go haywire for a couple hours.
Patient Q&A Section about dobutrex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is dobutrex used for?
"Dobutamine is a drug that is used to stimulate the heart muscle and improve blood flow. It is typically used in cases where the heart muscle has weakened and other heart medications have not been successful."
Answered by AI
Does dobutrex increase heart rate?
"Dobutamine primarily increases stroke volume and cardiac output in healthy animals due to its inotropic effects. There is also a small increase in heart rate, which is a minor contribution to the increase in cardiac output."
Answered by AI
Does dobutrex increase blood pressure?
"Dobutamine increases heart rate and blood pressure, especially systolic pressure. In clinical studies, 10% of patients had an increase in heart rate of 30 beats per minute or more, and 7.5% had an increase in systolic pressure of 50 mm Hg or more."
Answered by AI
What type of drug is dobutrex?
"Dobutrex is a synthetic catecholamine that helps improve the heart's pumping ability by strengthening the heart muscle. It also helps improve blood flow and relieve symptoms associated with heart failure."
Answered by AI