Dobutrex

Therapeutic procedure, Coronary Disease, Heart Attack + 3 more
Treatment
2 FDA approvals
20 Active Studies for Dobutrex

What is Dobutrex

DobutamineThe Generic name of this drug
Treatment SummaryDobutamine is a drug used to increase the strength of heart contractions, making it useful for treating heart conditions such as after a heart attack or open heart surgery. It works by stimulating the beta-1 receptors in the heart without causing an increase in heart rate or narrowing of the blood vessels.
Dobutamine Hydrochloride in Dextroseis the brand name
image of different drug pills on a surface
Dobutrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dobutamine Hydrochloride in Dextrose
Dobutamine
1993
22

Approved as Treatment by the FDA

Dobutamine, otherwise called Dobutamine Hydrochloride in Dextrose, is approved by the FDA for 2 uses like Cardiac Decompensation and Heart Failure .
Cardiac Decompensation
Helps manage Cardiac Decompensation
Heart Failure
Helps manage Cardiac Decompensation

Effectiveness

How Dobutrex Affects PatientsDobutamine is a drug that strengthens the heart and increases its ability to pump blood. It works by activating the beta-1 adrenergic receptors in the heart, but has only small effects on other types of receptors. Unlike dopamine, it does not cause the body to produce more norepinephrine.
How Dobutrex works in the bodyDobutamine helps the heart pump more blood by stimulating the beta-1 receptors in the heart. This increases the amount of blood the heart pumps out, resulting in a greater cardiac output.

When to interrupt dosage

The quantity of Dobutrex is contingent upon the identified disorder, including Heart Attack, Cardiac Surgical Procedures (D006348) and Coronary Artery Disease (CAD). The amount of dosage is contingent upon the technique of delivery (e.g. Intravenous or Liquid - Intravenous) specified in the following table.
Condition
Dosage
Administration
Heart Failure
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Coronary Disease
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Heart Attack
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Cardiac Surgical Procedures (D006348)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Therapeutic procedure
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Stress Echocardiography (SE)
, 12.5 mg/mL, 4.0 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.5 mg/mL, 25.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Liquid, Liquid - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous

Warnings

Dobutrex has one contraindication, and should not be utilized if any of the conditions in the following table are present.Dobutrex Contraindications
Condition
Risk Level
Notes
Cardiomyopathy, Hypertrophic
Do Not Combine
There are 20 known major drug interactions with Dobutrex.
Common Dobutrex Drug Interactions
Drug Name
Risk Level
Description
Iobenguane
Major
Dobutamine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.
1-benzylimidazole
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Minor
The risk or severity of hypertension can be increased when Dobutamine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
image of a doctor in a lab doing drug, clinical research

Dobutrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Dobutrex?

63 active studies are presently investigating the potential of Dobutrex to effectuate Therapeutic procedure, Cardiac Decompensation and Myocardial Infarction.
Condition
Clinical Trials
Trial Phases
Heart Failure
0 Actively Recruiting
Heart Attack
23 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Stress Echocardiography (SE)
0 Actively Recruiting
Coronary Disease
1 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting
Cardiac Surgical Procedures (D006348)
0 Actively Recruiting

Dobutrex Reviews: What are patients saying about Dobutrex?

2.7Patient Review
3/16/2009
Dobutrex for Failure of the Heart to Maintain Adequate Circulation
1Patient Review
10/5/2010
Dobutrex for Failure of the Heart to Maintain Adequate Circulation
We had to convince the medical staff multiple times to stop giving this medication to our son while he was in the ICU. Every time they administered it, his vitals would drop and everything would go haywire for a couple hours.
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Patient Q&A Section about dobutrex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is dobutrex used for?

"Dobutamine is a drug that is used to stimulate the heart muscle and improve blood flow. It is typically used in cases where the heart muscle has weakened and other heart medications have not been successful."

Answered by AI

Does dobutrex increase heart rate?

"Dobutamine primarily increases stroke volume and cardiac output in healthy animals due to its inotropic effects. There is also a small increase in heart rate, which is a minor contribution to the increase in cardiac output."

Answered by AI

Does dobutrex increase blood pressure?

"Dobutamine increases heart rate and blood pressure, especially systolic pressure. In clinical studies, 10% of patients had an increase in heart rate of 30 beats per minute or more, and 7.5% had an increase in systolic pressure of 50 mm Hg or more."

Answered by AI

What type of drug is dobutrex?

"Dobutrex is a synthetic catecholamine that helps improve the heart's pumping ability by strengthening the heart muscle. It also helps improve blood flow and relieve symptoms associated with heart failure."

Answered by AI

Clinical Trials for Dobutrex

Image of St Boniface Hospital in Winnipeg, Canada.

Remote Home Monitoring for Heart Attack

18+
All Sexes
Winnipeg, Canada
Heart attacks are one of the top causes of death in Canada, with over 2,100 cases treated each year in Manitoba. Even though hospital care has improved, the period after going home is still risky. Many patients feel anxious and unsure about their recovery, and without enough support, they often end up back in the emergency department (ED). This is an even bigger challenge for people in rural areas, where getting follow-up care can be much harder. Filling these gaps is important to help patients get better and to reduce stress on the healthcare system. In a previous study, the investigators found that extra support made a big difference: only 8% of participants using a digital health tool returned to the ED within 30 days, compared to 22% of participants without it. Now, the investigators want to expand this study across Manitoba to see if digital health tools can help more people recover safely at home. The investigators will compare two types of follow-up care: education only versus education with extra support (like symptom tracking and virtual appointments). The investigators will look at how this affects hospital visits, mental well-being, and healthcare costs. The goal is to create a better support system for people after a heart attack, leading to healthier recoveries, less strain on hospitals, and better care for Manitobans - no matter where they live.
Waitlist Available
Has No Placebo
St Boniface Hospital
Image of Baystate Medical Center in Springfield, United States.

Consent Approaches for Heart Disease Rehabilitation

18+
All Sexes
Springfield, MA
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend. New strategies are needed to help more patients attend cardiac rehabilitation. In this study, the investigators will see if using an $50 incentive, case management, text messages, and physical activity coaching combined into a single intervention will help more patients attend cardiac rehabilitation. In preparation for a larger trial, patients will also be randomly assigned to four different ways of seeking their permission to be in a research study. The investigators will see if these approaches affect how many people participate in the research project. The two main goals of this study is to understand: 1. If the consent approach type impacts participation rates in the research study 2. If the multi-component intervention (case management, financial incentives, text messages, and physical activity coaching) improves cardiac rehabilitation participation within 3 months.
Waitlist Available
Has No Placebo
Baystate Medical CenterQuinn R Pack, MD, MSc
Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.Go to Trials
Image of The Ohio State University Wexner Medical Center in Columbus, United States.

Health Coaching for Cardiovascular Disease

18+
All Sexes
Columbus, OH
For patients discharged with a diagnosis of cardiovascular disease coronary artery disease resulting in myocardial infarction and/or congestive heart failure, this study will evaluate if the addition of 12 virtual health coaching sessions over the course of 16 weeks will improve physiological, psychological, and social health outcomes, prove acceptable and satisfactory for these patients with CVD, decrease CVD-related questions and concerns sent to the provider via MyChart, and reduce hospital readmission rates over a 90-day period as compared to patients discharged with the same diagnosis who receive standard post-discharge care. The study will also evaluate the perceptions of physician and advanced practice providers related to the health coach as part of the interprofessional team and the amount of time spent addressing CVD-related patient questions and concerns via MyChart messages.
Waitlist Available
Has No Placebo
The Ohio State University Wexner Medical CenterBeth Steinberg, PhD, RN
Image of University of Tennessee Medical Center in Knoxville, United States.

Pharmacy Intervention for Medication Adherence

18+
All Sexes
Knoxville, TN
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of readmissions and costs among these patients. Major patient-reported barriers to essential medication use after hospital discharge among low-income individuals are related to social determinants of health (SDOH) and include: 1) financial barriers , 2) transportation barriers, and 3) system-level barriers. Although, medication therapy management services are important during care transitions, these services have not proven effective in improving medication adherence after hospital discharge, highlighting a critical need for innovative interventions. The Medication Affordability, Accessibility, and Availability in Care Transitions (Med AAAction) Study will test the effectiveness of a pharmacy-led care transitions intervention versus usual care through a pragmatic randomized controlled trial of 388 Medicaid and uninsured hospital in-patients with MCC from three large healthcare systems in Tennessee. The intervention will involve: 1) medications with zero copay, 2) bedside delivery then home delivery of medications, and 3) care coordination provided by certified pharmacy technicians/health coaches to assist with medication access, medication reconciliation, and rapid and ongoing primary care follow-up. We will examine the impact of the intervention during 12 months on 1) medication adherence (primary outcome) and 2) rapid primary care follow-up, 30-day readmissions, hospitalizations and emergency department visits, and costs. We will conduct key informant interviews to understand patient experience with the acre received during and after care transitions. By examining effectiveness of the intervention on outcomes including medication adherence, health care utilization, costs, and patient experience, this study will provide valuable results to health systems, payers, and policymakers to assist in future implementation and sustainability of the intervention for socioeconomically disadvantaged populations.
Recruiting
Senior-friendly
University of Tennessee Medical Center (+1 Sites)Satya Surbhi, PhD
Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.Go to Trials
Image of Rancho Los Amigos National Rehabilitation Center in Downey, United States.

BP REACH Intervention for High Blood Pressure

18+
All Sexes
Downey, CA
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services healthcare system. The goal of this clinical trial is to test if this team based program is better at helping people reduce their blood pressure than usual care for people with prior heart attack or stroke. The main questions it aims to answer are: * Do people in the REACH BP program have lower blood pressure at 12 months compared to those getting usual care? * Do people in the REACH BP program have better Life's Essential 8 scores and patient experience compared to those getting usual care?
Recruiting
Has No Placebo
Rancho Los Amigos National Rehabilitation Center (+3 Sites)Alejandra Casillas, MD
Have you considered Dobutrex clinical trials? We made a collection of clinical trials featuring Dobutrex, we think they might fit your search criteria.Go to Trials
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