Hetlioz
Sleep Disorders, Circadian Rhythm, Insomnia, Smith-Magenis Syndrome
Treatment
4 Active Studies for Hetlioz
Treatment for
Sleep Disorders, Circadian Rhythm
What is Hetlioz
Tasimelteon
The Generic name of this drug
Treatment Summary
Tasimelteon is a drug used to treat Non-24-Hour Sleep-Wake Disorder (N24HSWD) which mainly affects people who are blind. People with this condition often have trouble sleeping at night and feeling tired during the day. Tasimelteon helps to regulate the body’s circadian rhythm by activating melatonin receptors in the brain, allowing people with N24HSWD to sleep better. It is the only medication approved by the FDA specifically for this condition and was granted orphan drug status in 2010.
Hetlioz
is the brand name
Hetlioz Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hetlioz
Tasimelteon
2014
4
Effectiveness
How Hetlioz works in the body
Tasimelteon activates two types of melatonin receptors in the body.
When to interrupt dosage
The suggested measure of Hetlioz is contingent upon the determined condition. The quantity of dosage can be found in the table below, contingent upon the approach of administration (e.g. Suspension - Oral or Oral).
Condition
Dosage
Administration
Sleep Disorders, Circadian Rhythm
, 20.0 mg, 4.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension - Oral, Suspension
Insomnia
, 20.0 mg, 4.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension - Oral, Suspension
Smith-Magenis Syndrome
, 20.0 mg, 4.0 mg/mL
, Oral, Capsule, Capsule - Oral, Suspension - Oral, Suspension
Warnings
There are 20 known major drug interactions with Hetlioz.
Common Hetlioz Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Tasimelteon is combined with Deutetrabenazine.
Ethanol
Major
Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Tasimelteon is combined with Oliceridine.
Sodium oxybate
Major
Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Hetlioz Toxicity & Overdose Risk
Common side effects of tasimelteon include headaches, increased liver enzymes, nightmares, and infections in the upper respiratory or urinary tract. It has not been proven safe to take during pregnancy, and studies on animals suggest that it might be toxic to unborn babies. Additionally, rats did not try to seek out the drug during tests, meaning it is unlikely to be addictive.
Hetlioz Novel Uses: Which Conditions Have a Clinical Trial Featuring Hetlioz?
An ongoing research trial is assessing the potential of Hetlioz to reduce the symptoms of Non 24 Hour Sleep Wake Disorder.
Condition
Clinical Trials
Trial Phases
Sleep Disorders, Circadian Rhythm
0 Actively Recruiting
Smith-Magenis Syndrome
1 Actively Recruiting
Not Applicable
Insomnia
3 Actively Recruiting
Not Applicable
Patient Q&A Section about hetlioz
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is HETLIOZ used for?
"HETLIOZ® should be taken before bedtime.
The capsules are indicated for the treatment of: Non-24-Hour Sleep-Wake Disorder (Non-24) in adults and nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) patients 16 years of age and older."
Answered by AI
How do you take HETLIOZ?
"Your doctor may recommend that you take HETLIOZ® once a day, before bedtime. Make sure to swallow HETLIOZ® whole and take it without food. HETLIOZ® may cause drowsiness, so after taking it limit your activity to preparing for bed."
Answered by AI