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What is Methenamine Hippurate
MethenamineThe Generic name of this drug
Treatment SummaryMethenamine is a medication used to treat urinary tract infections. It is sold in salt form, such as methenamine hippurate, a salt of methenamine and hippuric acid. It has a unique cage-like structure that is similar to adamantane.
Hiprexis the brand name
Methenamine Hippurate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hiprex
Methenamine
1976
17
Approved as Treatment by the FDA
Methenamine, commonly known as Hiprex, is approved by the FDA for 2 uses such as prophylaxis of urinary tract infections and Urinary Tract Infections .prophylaxis of urinary tract infections
Urinary Tract Infections
Effectiveness
How Methenamine Hippurate Affects PatientsTaking one gram of methenamine hippurate will start to work in 30 minutes, fighting bacteria in the urine. Taking one gram twice daily will keep bacteria at bay.
How Methenamine Hippurate works in the bodyMethenamine only works in acidic environments. When it encounters an acidic environment, it is broken down into formaldehyde, an antibacterial substance. Formaldehyde damages proteins and genetic material in bacteria, killing them. The salt component of the drug helps keep the environment acidic so the formaldehyde can work.
When to interrupt dosage
The measure of Methenamine Hippurate is dependent upon the indicated affliction. The dosage similarly fluctuates as per the technique of delivery, as outlined in the table beneath.Condition
Dosage
Administration
prophylaxis of urinary tract infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical
Urinary Tract Infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical
Warnings
Methenamine Hippurate has four contraindications. It should not be taken if any of the conditions listed in the table below are present.Methenamine Hippurate ContraindicationsCondition
Risk Level
Notes
Liver Failure
Do Not Combine
Dehydration
Do Not Combine
Renal Insufficiency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Methenamine Hippurate Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Methenamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Methenamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Methenamine.
Acetyl sulfisoxazole
Major
Methenamine can cause a decrease in the absorption of Acetyl sulfisoxazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amphetamine
Major
The serum concentration of Amphetamine can be decreased when it is combined with Methenamine.
Methenamine Hippurate Toxicity & Overdose RiskLess than 3.5% of patients who take this drug may experience mild side effects like disturbed stomach, difficulty passing urine, nausea, and skin rash.
Methenamine Hippurate Novel Uses: Which Conditions Have a Clinical Trial Featuring Methenamine Hippurate?
Ten active studies are currently being conducted to analyze the potential of Methenamine Hippurate to address Urinary Tract Infections.Condition
Clinical Trials
Trial Phases
prophylaxis of urinary tract infections
0 Actively Recruiting
Urinary Tract Infections
2 Actively Recruiting
Not Applicable
Methenamine Hippurate Reviews: What are patients saying about Methenamine Hippurate?
5Patient Review
2/3/2016 Overall, this medication has helped me a lot. The only downside is that it gives me an unpleasant taste in my mouth.
5Patient Review
7/30/2016 This medication has been a literal lifesaver. I no longer have to constantly worry about UTIs, and can't remember the last time I've had one.
5Patient Review
9/23/2018 This treatment has been a godsend for me. I've struggled with recurrent UTIs for the past 2 1/2 years, and this medication has finally helped put an end to that. So far, so good! I haven't experienced any negative side effects, either.
5Patient Review
5/26/2021 This medication has completely changed my life for the better. I used to get UTIs almost monthly, and now it's been over a year since I've had one.
5Patient Review
8/20/2015 I've had UTIs for my entire adult life, and this is the first medication that has given me any relief.
5Patient Review
3/7/2018 I've had chronic UTIs for years, and this medication has finally provided some relief. I haven't had an infection in five months!
5Patient Review
9/4/2020 I was getting UTIs monthly, which my urologist addressed by putting me on a low dose antibiotic for three months. Additionally, I took methenamine and Vitamin C, as well as cranberry supplements. I'm now over a year UTI-free and can say that the relief is worth the nasty taste of the pills.
4.3Patient Review
11/2/2019 This treatment really worked for me. After years of UTIs and becoming antibiotic resistant or allergic, I found this approach. I've been UTI-free for a year now. Because I become resistant to meds so easily, I cut the pills in half and take half dosages, which are also easier to swallow. They're not easy to get down even then, but certainly worth the inconvenience and occasional gagging.
4Patient Review
5/4/2017 So far, this is the only treatment that has kept my urinary tract infection free. I just hope I can keep taking it without any adverse effects.
4Patient Review
5/3/2019 I'm 24 and have been struggling with IC and chronic UTIs for about 5 years now. Hiprex really helps me when I get a UTI (which has happened 4 times in the last 3 months). I am hesitant to use it long-term because of potential side effects, but so far it's been good. The only downside is that it causes burning if I'm not super hydrated, but overall it's a lifesaver.
4Patient Review
12/23/2021 I've been taking this for three months now, and it's really helped me with my UTI problem. I'm wondering if anyone else has taken it for such a long time though?
4Patient Review
4/14/2020 The pill was difficult for me to swallow, so I crushed it between two spoons and mixed it with a drop of milk.
3.7Patient Review
1/17/2021 This drug is great for preventing cystitis. The only downside is that the tablets are a bit difficult to swallow.
3Patient Review
6/5/2021 I've been taking this for about two weeks now, and I find it hard to swallow the pill even when I cut it in half.
2.7Patient Review
7/18/2022 If you have liver issues, this drug can cause problems. You'll need to get your liver checked every few months while taking it.
2.3Patient Review
7/10/2018 After 7 UTIs in 18 months, I went on a 3-month course of antibiotics, which seemed to work. I started taking Methenamine Hippurate as a preventative measure and everything was fine for about 2 months. Then I started having pain and incontinence typical of another UTI. There was no UTI; just the side effects of the drug. It has been a month since I stopped taking it, and the incontinence persists.
2.3Patient Review
6/4/2018 The taste and texture make it really hard to get this pill down. I've tried two versions and neither were any better. Is there a coated pill I can ask for? I'll be on this medication long-term, so something easy to swallow would be great.
Patient Q&A Section about methenamine hippurate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is methenamine hippurate an antibiotic?
"The antibiotic methenamine eliminates bacteria that cause urinary tract infections, and is usually used to treat chronic infections or prevent the recurrence of infections."
Answered by AI
How long should you take methenamine hippurate?
"If you take more than the prescribed amount of methenamine hippurate (Hiprex) for more than 3 weeks, you may experience bladder irritation, frequent and painful urination, protein in your urine, and bloody urine."
Answered by AI
Does methenamine hippurate treat UTI?
"Methenamine hippurate may be effective for preventing UTI in patients without renal tract abnormalities, particularly when used for short-term prophylaxis. It does not appear to be effective in patients with neuropathic bladder or in patients who have renal tract abnormalities."
Answered by AI
What does methenamine hippurate do?
"Methaenamine is used to stop urinary tract infections that are caused by bacteria. It cannot be used to treat an infection that is already happening. It also won't work for colds, the flu, or other viral infections. This medicine may be able to be used for other things; if you have questions, ask your health care provider or pharmacist."
Answered by AI