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What is Propulsid
CisaprideThe Generic name of this drug
Treatment SummaryCisapride is a medication that was used to treat gastrointestinal disorders, however it has been withdrawn from the market or had its use restricted in many countries due to reports of long QT syndrome which puts patients at risk of abnormal heart rhythms. The US FDA has issued a warning letter to healthcare professionals and patients about the risks associated with cisapride.
Propulsidis the brand name
Propulsid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propulsid
Cisapride
1993
3
Approved as Treatment by the FDA
Cisapride, also known as Propulsid, is approved by the FDA for 2 uses like Gastrointestinal Disorder and Gastrointestinal Diseases .Gastrointestinal Disorder
Gastrointestinal Diseases
Effectiveness
How Propulsid Affects PatientsCisapride is a drug that helps improve the movement of food through the upper digestive tract. It works by activating serotonin 5-HT receptors, which in turn releases a chemical called acetylcholine that helps increase the tone and strength of stomach contractions and relaxes the muscles in the pyloric sphincter and duodenal bulb. Cisapride also helps to speed up the emptying of the stomach and transit of food through the intestines, and increases the tension of the lower esophageal sphincter. It does not affect the movement of food through the colon or gallbladder
How Propulsid works in the bodyCisapride helps move food through the digestive system by stimulating serotonin receptors in the enteric nervous system. This increases the tone and strength of stomach and intestinal contractions, as well as relaxing the pyloric sphincter and duodenal bulb, to help move food quickly through the digestive system.
When to interrupt dosage
The suggested measure of Propulsid is contingent upon the diagnosed state. The amount of dosage is contingent upon the method of delivery as featured in the table below.Condition
Dosage
Administration
Gastrointestinal Diseases
10.0 mg, , 5.0 mg, 20.0 mg, 1.0 mg/mL
, Oral, Tablet - Oral, Tablet, Suspension, Suspension - Oral
Warnings
Propulsid ContraindicationsCondition
Risk Level
Notes
increased gastrointestinal motility
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Cardiac Arrhythmia
Do Not Combine
Common Propulsid Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Cisapride.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Cisapride.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Cisapride.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Cisapride.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Cisapride.
Propulsid Novel Uses: Which Conditions Have a Clinical Trial Featuring Propulsid?
Currently, there are 6 trials assessing the utility of Propulsid in managing Gastrointestinal Disorders.Condition
Clinical Trials
Trial Phases
Gastrointestinal Diseases
7 Actively Recruiting
Phase 1, Not Applicable, Phase 2
Propulsid Reviews: What are patients saying about Propulsid?
5Patient Review
10/22/2008 I was really bummed when this medication was taken off the market because it was the only one that helped my stomach problems. There are other medications with serious side effects that are still available, so I don't understand why this one was removed.
5Patient Review
5/14/2012 I don't understand why this medication was taken off the market; it worked really well for me. In fact, it was the only medicine for GERD that my doctor tried out on me that actually worked.
5Patient Review
6/17/2014 I was so disappointed when this medicine was taken off the market. It was the only one that worked for my GERD and stomach problems. I haven't been able to find anything else that works as well since then.
4Patient Review
6/7/2010 I really rely on this medication to help me drink water. It's effective and I've never experienced any negative side effects.
1.7Patient Review
3/25/2010 My son was given this for GERD for almost four years, and it did not help him. In fact, once it was pulled from the market, my son (now thirteen) still had a touch of GERD. He was recently diagnosed with EE—an allergic inflammatory disease of his esophagus. I wonder if he would have been better off without this medication?
Patient Q&A Section about propulsid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Propulsid used for?
"Cisapride is a medication that helps improve the movement of the gastrointestinal system. It is used to treat conditions such as stasis, reflux, and constipation/megacolon in cats."
Answered by AI
Why was Propulsid taken off the market?
"The FDA announced on March 23, 2000 that Propulsid would be taken off the market as of July as a normally prescribed drug because of frequent heart-rhythm deaths. In total, Propulsid has been blamed for 302 deaths."
Answered by AI
When was Propulsid removed from market?
"As of July 14, 2000, Janssen Pharmaceutica Inc. of Titusville, New jersey will no longer be marketing cisapride, also known as Propulsid. This voluntary action is being taken in order to give patients and physicians enough time to look into alternative treatments."
Answered by AI
Is there a replacement for Propulsid?
"Since Propulsid is no longer available, what prokinetic agent do you use to treat GERD? Dr. Marks: Reglan (or metoclopramide) is the only prokinetic agent available."
Answered by AI