Endoscopy for Stomach Cancer Detection and Prevention

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byHaejin In, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Rutgers, The State University of New Jersey

No Placebo Group

Trial Summary

What is the purpose of this trial?

Screening esophagogastroduodenoscopy (EGD )provides three distinct opportunities to decrease gastric cancer (GC) morbidity and mortality. has potential to discover cancer in early stages before the onset of symptoms, leading to higher rates of survival. Second, premalignant lesions such as adenomatous polyps, intestinal metaplasia and dysplasia can be discovered and removed with local resection, akin to polypectomies during screening colonoscopies, preventing the development of cancer. Third, EGD discovery and treatment of active Helicobacter pylori (HP) infection of the stomach provides an opportunity for primary prevention of GC.

Eligibility Criteria

This trial is for individuals aged between 40 and 80 who haven't had an esophagogastroduodenoscopy (EGD) in the last five years. It's especially aimed at those at high risk of stomach cancer, willing to follow the study rules, and planning to have a colonoscopy. People with conditions that make EGD risky or previous stomach surgery are excluded.

Inclusion Criteria

Half of the recruited subjects will be from high-risk groups

Willing and able to comply with all aspects of the protocol

I am scheduled for a colonoscopy.

See 3 more

Exclusion Criteria

Had EGD in the last five years

I have had my entire stomach surgically removed.

Medical conditions that substantially increase risks for EGD

See 1 more

Treatment Details

Interventions

esophagogastroduodenoscopy (EGD) (Procedure)

Trial OverviewThe pilot study tests whether early detection and prevention of stomach cancer can be achieved through EGD screening. The procedure may identify early-stage cancers, remove precancerous growths like polyps, and treat Helicobacter pylori infections to prevent future cancer development.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: EGD at time of routine screening colonoscopyExperimental Treatment1 Intervention

This happens on Day 0. Screening for EGD, biopsy samples from esophagus, stomach, gastrointestinal junction, and duodenum AE's.