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Corticosteroid

Dexamethasone for Bone Grafting After Tooth Extractions

Phase < 1
Recruiting
Led By Brian L Mealey, DDS, MS
Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
One tooth, excluding molars, that has been identified by dental faculty as requiring a single tooth extraction
Site has at least 10mm of alveolar bone height, without impinging on the maxillary sinus or inferior alveolar canal
Must not have
Will not cooperate with the follow-up schedule
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 16 weeks (±2 weeks)
Awards & highlights

Summary

"This trial investigates the use of bone grafts in tooth sockets after tooth removal to prevent bone loss. The bone graft, made from human tissue donors, is dehydrated before being placed in the socket

Who is the study for?
This trial is for individuals needing a tooth extraction followed by bone grafting, known as 'Ridge Preservation'. Participants should be suitable candidates for receiving a bone allograft. Specific inclusion and exclusion criteria details are not provided.
What is being tested?
The study tests the effectiveness of rehydrating freeze-dried bone allografts with dexamethasone solution compared to saline during ridge preservation after tooth extractions. The goal is to see if dexamethasone improves outcomes.
What are the potential side effects?
Potential side effects may include local reactions at the graft site, such as swelling or pain. Systemic side effects from dexamethasone could involve changes in blood sugar levels and increased risk of infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I need one tooth pulled out, but it's not a molar.
Select...
I have enough jawbone height for the procedure, without affecting my sinus or nerve canal.
Select...
I am scheduled to get a dental implant for my missing tooth.
Select...
My tooth socket's bone wall is partially open but not more than half its depth.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am willing and able to follow the study's follow-up schedule.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 16 weeks (±2 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 16 weeks (±2 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percentage of Bone Formation
Secondary study objectives
Buccal Ridge Height
Lingual Ridge Height
Ridge Width

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Ridge preservation test groupExperimental Treatment1 Intervention
Patients will be randomized to one of the experimental treatment group immediately following tooth extraction and debridement of the socket (test: hydration of allograft with 4mg/1ml dexamethasone solution)
Group II: Ridge preservation control groupActive Control1 Intervention
Patients will be randomized to the control group immediately following tooth extraction and debridement of the socket (control: hydration of allograft with normal saline solution)

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
467 Previous Clinical Trials
91,720 Total Patients Enrolled
3 Trials studying Tooth Extractions
111 Patients Enrolled for Tooth Extractions
Brian L Mealey, DDS, MSPrincipal InvestigatorThe University of Texas Health Science Center at San Antonio
4 Previous Clinical Trials
184 Total Patients Enrolled
1 Trials studying Tooth Extractions
40 Patients Enrolled for Tooth Extractions
~29 spots leftby Dec 2026
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