Popular Trials
Procedure
CTIF vs LNF for Acid Reflux
This trial compares two treatments, TIF and LNF, for patients with acid reflux and a hiatal hernia who are having hernia repair surgery. TIF is a non-surgical procedure done through the mouth, while LNF is a minimally invasive surgery. Both aim to stop acid reflux by improving the valve between the stomach and esophagus.
Reinforced Tissue Matrix
OviTex Mesh for Hernia Repair
This trial is testing a special mesh called OviTex in patients with ventral or inguinal hernias who are having robotic surgery. The goal is to see if this mesh can lower the risk of complications and prevent the hernia from returning. OviTex is designed to provide better support for the abdominal wall.
Procedure
Local vs General Anesthesia for Inguinal Hernia Repair in Older Adults
This trial aims to determine which type of anesthesia is best for hernia repair in older adults: general or local. It seeks to address unanswered questions about the effects of anesthetic technique on cognitive function and quality of life.
Popular Filters
Trials for Congenital Diaphragmatic Hernia Patients
Inotrope and Lusitrope
Milrinone for Congenital Diaphragmatic Hernia
This trial is testing if milrinone, a medicine that helps the heart and lungs, can improve oxygen levels in newborns with severe lung and heart problems due to CDH. These babies often don't get better with usual treatments. The goal is to see if milrinone can safely help these babies breathe easier. Milrinone is used in up to 30% of CDH infants across the United States, but no studies have tested its effectiveness or safety in these newborns.
Device
FETO for Congenital Diaphragmatic Hernia
This trial is testing a new prenatal treatment for babies with congenital diaphragmatic hernia (CDH). CDH is a birth defect where the diaphragm, the muscle that separates the chest from the abdomen, doesn't form correctly. This can cause the intestines and other abdominal organs to push up into the chest, and can prevent the lungs from developing properly. CDH can be diagnosed prenatally with ultrasound or MRI, and the severity can be estimated by the size of the lungs. This trial is testing a new treatment called fetoscopic endotracheal occlusion (FETO) where a balloon is placed
Procedure
FETO Surgery for Congenital Diaphragmatic Hernia
This trial is testing a new fetal therapy for babies with severe Congenital Diaphragmatic Hernia (CDH). The goal is to improve neonatal survival rates by increasing lung growth while the baby is still in the womb.
Trials for CDH Patients
Inotrope and Lusitrope
Milrinone for Congenital Diaphragmatic Hernia
This trial is testing if milrinone, a medicine that helps the heart and lungs, can improve oxygen levels in newborns with severe lung and heart problems due to CDH. These babies often don't get better with usual treatments. The goal is to see if milrinone can safely help these babies breathe easier. Milrinone is used in up to 30% of CDH infants across the United States, but no studies have tested its effectiveness or safety in these newborns.
Device
FETO for Congenital Diaphragmatic Hernia
This trial is testing a new prenatal treatment for babies with congenital diaphragmatic hernia (CDH). CDH is a birth defect where the diaphragm, the muscle that separates the chest from the abdomen, doesn't form correctly. This can cause the intestines and other abdominal organs to push up into the chest, and can prevent the lungs from developing properly. CDH can be diagnosed prenatally with ultrasound or MRI, and the severity can be estimated by the size of the lungs. This trial is testing a new treatment called fetoscopic endotracheal occlusion (FETO) where a balloon is placed
Procedure
FETO Surgery for Congenital Diaphragmatic Hernia
This trial is testing a new fetal therapy for babies with severe Congenital Diaphragmatic Hernia (CDH). The goal is to improve neonatal survival rates by increasing lung growth while the baby is still in the womb.
Trials With No Placebo
Biomaterial
Gore ENFORM Device for Hernia Repair
This trial is studying a special material called GORE® ENFORM Biomaterial used in hernia repair surgeries. It focuses on patients with specific types of hernias to see how well this material works in real-world conditions. The material helps by acting as a supportive patch during surgery, making the repaired area stronger. GORE® ENFORM Biomaterial is a type of synthetic material used in hernia repair surgeries, known for its effectiveness in providing quick, simple, and effective repair of tissue defects in the abdominal wall.
Device
FETO for Congenital Diaphragmatic Hernia
This trial is testing a new prenatal treatment for babies with congenital diaphragmatic hernia (CDH). CDH is a birth defect where the diaphragm, the muscle that separates the chest from the abdomen, doesn't form correctly. This can cause the intestines and other abdominal organs to push up into the chest, and can prevent the lungs from developing properly. CDH can be diagnosed prenatally with ultrasound or MRI, and the severity can be estimated by the size of the lungs. This trial is testing a new treatment called fetoscopic endotracheal occlusion (FETO) where a balloon is placed
View More Related Trials
Frequently Asked Questions
Introduction to hernia
What are the top hospitals conducting hernia research?
Breaking new ground in the field of hernia research, several top hospitals across the United States are conducting clinical trials aimed at improving treatment options for this common condition. In Iowa City, the University of Iowa is making significant strides with three active hernia trials and a total of three recorded trials to date. Since their first trial in 2013, they have been committed to exploring innovative approaches for managing hernias.
Not too far away in Houston, Texas, two renowned institutions are also leading the way. The University of Texas Health Science Center has undertaken three ongoing hernia trials and has a history of four completed studies since initiating their first trial in 2015. Lyndon B. Johnson General Hospital, situated within the same city's medical landscape as its counterpart, is actively involved in three current hernia trials and stands proud with five previously conducted studies since recording their inaugural trial also back in 2015.
Meanwhile,the Cleveland Clinic Center for Abdominal Core Health located at Cleveland showcases commitment through recent initiation(2019)of multiple such clinical ventures (three,to be precise).The institution keeps pace alongside counterparts with previous accomplishments being four specifically focused on tacklinghernias
Last but not least,in Lexington,the University Of Kentucky stands strong by demonstrating dedication towards curbing this health issue.Its participation includes two currently held clinical assessments while maintaining required momentum from holding seven prior investigations accomplished ever since it's very beginning(dated2009)
These prestigious hospitals serve as vital hubs where groundbreaking discoveries can occur,resultingin improved treatmentsand potentially life-changing outcomesfor individuals suffering from hernias.Investigating various aspects related to diagnosis,surgical techniques,and post-operative care;these institutions offer hope not just regionallybut nationwideas they continue striding forward collectivelytowardscreatinga worldwhere those affectedbythisconditioncan live more comfortable lives
Which are the best cities for hernia clinical trials?
Houston, Texas; Cleveland, Ohio; and Columbus, Ohio emerge as the top cities for hernia clinical trials. Houston leads with 18 ongoing studies focusing on various surgical approaches like early inguinal hernia repair and open repair under local anesthesia. Cleveland follows closely behind with 9 active trials exploring interventions such as milrinone and anterior gastropexy. Lastly, Columbus boasts 6 active trials investigating treatments such as supervised physical therapy and the Rebound hernia repair device without fixation. These cities offer individuals with hernias access to cutting-edge clinical research that aims to improve treatment outcomes and advance medical knowledge in this field.
Which are the top treatments for hernia being explored in clinical trials?
Exciting progress is being made in the field of hernia treatment, with several innovative approaches being explored through clinical trials. Leading the charge is FETO therapy, which has shown promise in two active trials and gained attention since its introduction in 2015. Another promising contender is the Catheter System, currently involved in two ongoing trials after its recent listing in 2022. Additionally, Supervised Physical Therapy has emerged as a new avenue for investigation with one active trial underway. Finally, Mesh Implantation continues to be studied extensively with one ongoing trial since its initial listing back in 2006. These advancements hold great potential for improving outcomes and quality of life for individuals affected by hernias.
What are the most recent clinical trials for hernia?
Exciting advancements in hernia treatment are underway through recent clinical trials. One notable study focuses on the use of minimal opioids, aiming to reduce the reliance on these medications for postoperative pain management. Another trial explores the effectiveness of BOTOX at different dosage levels in treating hernias, offering potential alternatives to traditional approaches. Additionally, sildenafil citrate is being investigated as a possible therapeutic option for hernia patients. Furthermore, quality-of-life assessments play a vital role in understanding and improving outcomes for individuals with hernias. These innovative trials hold promise for enhanced patient care and improved treatment strategies moving forward.
What hernia clinical trials were recently completed?
Recently completed clinical trials have made significant strides in advancing hernia treatments. In April 2021, Innocoll successfully concluded a trial investigating the INL-001 implant, an innovative bupivacaine hydrochloride treatment option. Another noteworthy trial was completed in May 2018 by Seikagaku Corporation, examining the efficacy of SI-6603 for hernia management. These recent achievements underscore the ongoing efforts to improve outcomes and provide hope for patients affected by this common condition.