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Monoclonal Antibodies

Study of LM-102 in Subjects in Advanced Tumors

Phase 1
Waitlist Available
Research Sponsored by LaNova Medicines Limited
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (week 0) through approximately 1 year after first administration of lm102
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a new drug called LM-102 in patients with a specific type of advanced cancer. The drug will be given periodically, and its safety and effectiveness will be monitored.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (week 0) through approximately 1 year after first administration of lm102
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 0) through approximately 1 year after first administration of lm102 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Electrocardiogram (ECG)-QRS duration
Change in Electrocardiogram (ECG)-QT interval
Change in Electrocardiogram (ECG)-RR interval
+10 more
Secondary study objectives
Area under the serum concentration versus time curve within one dosing interval (AUCtau)
Best of response (BOR)
Clearance (CL)
+11 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

5Treatment groups
Experimental Treatment
Group I: LM102 Dose Escalation Level 5, 40mg/kgExperimental Treatment1 Intervention
LM102 Dose Escalation Level 5, 40mg/kg,enrolled CLDN 18.2 positive advanced solid tumors
Group II: LM102 Dose Escalation Level 4, 30mg/kgExperimental Treatment1 Intervention
LM102 Dose Escalation Level 4, 30mg/kg,enrolled CLDN 18.2 positive advanced solid tumors
Group III: LM102 Dose Escalation Level 3, 20mg/kgExperimental Treatment1 Intervention
LM102 Dose Escalation Level 3, 20mg/kg,enrolled CLDN 18.2 positive advanced solid tumors
Group IV: LM102 Dose Escalation Level 2, 10mg/kgExperimental Treatment1 Intervention
LM102 Dose Escalation Level 2, 10mg/kg,enrolled CLDN 18.2 positive advanced solid tumors
Group V: LM102 Dose Escalation Level 1, 3mg/kgExperimental Treatment1 Intervention
LM102 Dose Escalation Level 1, 3mg/kg, enrolled CLDN 18.2 positive advanced solid tumors

Find a Location

Who is running the clinical trial?

LaNova Medicines LimitedLead Sponsor
10 Previous Clinical Trials
1,213 Total Patients Enrolled
~2 spots leftby Dec 2025
Unbiased ResultsWe believe in providing patients with all the options.
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