MRI-Guided Internal Radiation for Cervical and Vaginal Cancer

Recruiting in Palo Alto (17 mi)

Overseen byAnn H. Klopp

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: M.D. Anderson Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial studies how well magnetic resonance imaging (MRI)-guided internal radiation therapy (brachytherapy) works in treating participants with human papillomavirus (HPV) associated stage IB2-IV cervical or stage II-IVA vaginal cancer. Using MRI guidance during brachytherapy applicator placement may improve treatment planning in participants with cervical or vaginal cancer.

Research Team

Ann H. Klopp

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for women with stage IB2-IVA cervical cancer or stage II-IVA vaginal cancer, recommended to receive chemoradiation including brachytherapy. It's not suitable for those with non-MRI-compatible anatomy, pacemakers, defibrillators, or conditions that prevent MRI use.

Inclusion Criteria

Women with advanced stage cervical cancer who are recommended to receive a specific type of treatment called chemoradiation, including brachytherapy.

Women with a specific stage of vaginal cancer who are advised to undergo a specific type of treatment involving chemotherapy and radiation therapy.

Exclusion Criteria

Patient or tumor anatomy that requires use of a non-MRI-compatible applicator

Patients with implantable cardioverter-defibrillator, pacemaker or other implanted device or medical condition which precludes MRI acquisition.

Treatment Details

Interventions

Internal Radiation Therapy (Brachytherapy)
MRI-Guided Brachytherapy (Procedure)

Trial OverviewThe study tests if using MRI guidance to place the internal radiation therapy device (brachytherapy) can improve treatment planning and outcomes in participants with HPV-associated cervical or vaginal cancers.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Treatment (MRI, internal radiation therapy)Experimental Treatment2 Interventions

Participants undergo MRI scan during internal radiation therapy applicator placement.