Occupational Diseases > Etanercept
~2 spots leftby Apr 2026

Understanding GWI: Integrative Modeling

Recruiting in Palo Alto (17 mi)
NK
Overseen byNancy Klimas, MD
Age: 18+
Sex: Male
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1
Waitlist Available
Sponsor: South Florida Veterans Affairs Foundation for Research and Education
No Placebo Group

Trial Summary

What is the purpose of this trial?

The investigator proposes to perform a Phase I study assessing safety, efficacy, and biomarker response to the therapeutic interventions of Etanercept followed by mifepristone for veterans with Gulf War Illness. The investigator will conduct and repeat the exercise challenge before treatment and on therapy to assess the impact of the interventions on homeostatic regulation and the dynamic model identified in prior studies.

Research Team

NK

Nancy Klimas, MD

Principal Investigator

South Florida Veterans Affairs Foundation for Research and Education

Eligibility Criteria

Inclusion Criteria

Male Veterans who were deployed in 1990 -1991 Gulf War.
Veterans who currently meet the Kansas Gulf War Study Case Definition for Gulf War Illness.
Veterans who were in good health based on medical history prior to 1990.
See 2 more

Treatment Details

Interventions

  • Etanercept (Monoclonal Antibodies)
  • Mifepristone (Corticosteroid)
Participant Groups
2Treatment groups
Experimental Treatment
Group I: MifepristoneExperimental Treatment1 Intervention
(300 mg once a day for 7 days) will follow the etanercept.
Group II: EtanerceptExperimental Treatment1 Intervention
50 MG/ML Prefilled Syringe (once a week for 4 weeks)

Etanercept is already approved in Canada for the following indications:

🇨🇦
Approved in Canada as Enbrel for:
  • Rheumatoid Arthritis
  • Juvenile Idiopathic Arthritis
  • Psoriatic Arthritis
  • Ankylosing Spondylitis
  • Plaque Psoriasis

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
Miami VA Healthcare SystemMiami, FL
Loading ...

Who Is Running the Clinical Trial?

South Florida Veterans Affairs Foundation for Research and Education

Lead Sponsor

Trials
5
Patients Recruited
420+

United States Department of Defense

Collaborator

Trials
940
Patients Recruited
339,000+

Nova Southeastern University

Collaborator

Trials
103
Patients Recruited
12,000+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top