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Procedure

Personalized TMS for Stroke

N/A
Recruiting
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Upper extremity Fugl-Meyer score < 66
Presence of residual upper extremity hemiparesis
Must not have
Upper extremity Fugl-Meyer score = 66
History of neurological disease and/or neurological injury other than stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week
Awards & highlights
No Placebo-Only Group

Summary

"This trial will test if a personalized brain stimulation technique called transcranial magnetic stimulation (TMS) can help improve hand function in stroke patients. The goal is to see if this technique can activate certain

Who is the study for?
This trial is for individuals who have had a stroke and are experiencing hand function impairment. Participants should be able to undergo TMS treatments safely.
What is being tested?
The study is testing if personalized brain state-dependent TMS can better activate the corticospinal tract, which may improve hand movement after a stroke, compared to standard TMS.
What are the potential side effects?
TMS may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in very rare cases. Most side effects are mild and temporary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My arm and hand movement is significantly limited.
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I have weakness in one of my arms.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My arm and hand movements are near normal.
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I have a history of neurological conditions or injuries, but not including stroke.
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My brain does not respond to a specific test after a stroke or injury.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
MEP amplitudes
Upper Extremity Fugl-Meyer Assessment Summed Hand and Wrist Subscores

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Brain state-dependent TMS during strong statesExperimental Treatment1 Intervention
Group II: Brain state-dependent TMS during random statesActive Control1 Intervention

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Who is running the clinical trial?

University of Texas at AustinLead Sponsor
378 Previous Clinical Trials
86,572 Total Patients Enrolled
10 Trials studying Stroke
1,066 Patients Enrolled for Stroke
~25 spots leftby Aug 2026
Unbiased ResultsWe believe in providing patients with all the options.
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