Normal Saline for Postural Orthostatic Tachycardia Syndrome

Phase 1

Waitlist Available

Led By Marvin S. Medow, Ph.D.

Research Sponsored by New York Medical College

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 week

Awards & highlights

No Placebo-Only Group

Summary

This trial tests a special drink with water, sugar, and salt to help young ME/CFS patients who struggle with standing. The drink helps the body absorb water better, which can improve blood flow and reduce symptoms.

Eligible Conditions

Vasovagal Syncope
Chronic Fatigue Syndrome
Postural Orthostatic Tachycardia Syndrome

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 week

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 week

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

To test whether 1 Liter volumes of intravenous or oral rehydration solution increase total blood volume and cardiac output, comparably improving the threshold for orthostatic intolerance

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Oral rehydration solutionExperimental Treatment1 Intervention

Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.

Group II: Normal SalineExperimental Treatment1 Intervention

Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Oral Rehydration Solution

2021

Completed Phase 3

~30

Normal Saline

2019

Completed Phase 4

~1770