Popular Trials
Selective Estrogen Receptor Modulator (SERM)
Letrozole + Clomiphene Citrate for Anovulation
This trial tests if combining letrozole and clomiphene citrate helps women with PCOS ovulate better than using letrozole alone. Letrozole lowers estrogen to stimulate egg release, and clomiphene citrate boosts hormone production for the same purpose. The study aims to see if this combination increases the chances of ovulation. Clomiphene citrate has been widely used for over 50 years as a first-line therapy for ovulation induction in PCOS, while letrozole is a newer alternative that appears to improve live birth rates compared to clomiphene.
Antiandrogen
Hormone Therapy for Polycystic Ovary Syndrome
This trial is testing if flutamide, which blocks testosterone, can help women with PCOS improve their hormone regulation. The study aims to see if this medication can enhance the body's response to progesterone. Flutamide has been used to treat high levels of male hormones in women with PCOS, but its use is limited by potential liver damage and cost.
Dietary Supplement
Myo-Inositol + Letrozole for PCOS Infertility
This trial will compare the effect of letrozole with a placebo, versus letrozole with inositols, on pregnancy rates in women undergoing ovulation induction. The trial will be double-blind, meaning that neither the participants nor the research team will know which treatment each person is receiving.
Popular Filters
Trials for PCOS Patients
Beta3-Adrenergic Receptor Agonist
Mirabegron + B Complex Plus Vitamin C for Brown Adipose Tissue
This trial tests if the drug mirabegron can increase brown fat activity in people aged 18-40 with different body types. The drug helps brown fat burn more energy, which might aid in weight loss and better sugar management.
Biguanide
Metformin for Polycystic Ovary Syndrome
This trial is testing metformin, a common diabetes medication, to see if it can reduce liver fat in young people with polycystic ovary syndrome (PCOS). The study focuses on adolescents and young adults who have high liver fat and are at risk for non-alcoholic fatty liver disease (NAFLD). Metformin works by helping the body use insulin more effectively, which may lower liver fat. Metformin is an antidiabetic drug widely used to improve insulin resistance and has shown potential benefits in treating non-alcoholic fatty liver disease (NAFLD).
Behavioral Intervention
Fitness Support Group Program for Obesity
This trial is testing a program to get girls to exercise more and enjoy it more. They will do this by measuring how much they enjoy it before and after the program, as well as how it affects their risk for diseases.
Progestogen
Progesterone for Normal Puberty
This trial is testing whether or not giving progesterone to pubertal girls will prevent the nighttime increase of LH pulses. If successful, this could help researchers understand more about how menstrual cycles are established.
Trials for Polycystic Ovary Syndrome Patients
Beta3-Adrenergic Receptor Agonist
Mirabegron + B Complex Plus Vitamin C for Brown Adipose Tissue
This trial tests if the drug mirabegron can increase brown fat activity in people aged 18-40 with different body types. The drug helps brown fat burn more energy, which might aid in weight loss and better sugar management.
Biguanide
Metformin for Polycystic Ovary Syndrome
This trial is testing metformin, a common diabetes medication, to see if it can reduce liver fat in young people with polycystic ovary syndrome (PCOS). The study focuses on adolescents and young adults who have high liver fat and are at risk for non-alcoholic fatty liver disease (NAFLD). Metformin works by helping the body use insulin more effectively, which may lower liver fat. Metformin is an antidiabetic drug widely used to improve insulin resistance and has shown potential benefits in treating non-alcoholic fatty liver disease (NAFLD).
Behavioral Intervention
Fitness Support Group Program for Obesity
This trial is testing a program to get girls to exercise more and enjoy it more. They will do this by measuring how much they enjoy it before and after the program, as well as how it affects their risk for diseases.
Progestogen
Progesterone for Normal Puberty
This trial is testing whether or not giving progesterone to pubertal girls will prevent the nighttime increase of LH pulses. If successful, this could help researchers understand more about how menstrual cycles are established.
Trials With No Placebo
Behavioral Intervention
Fitness Support Group Program for Obesity
This trial is testing a program to get girls to exercise more and enjoy it more. They will do this by measuring how much they enjoy it before and after the program, as well as how it affects their risk for diseases.
Frequently Asked Questions
Introduction to polycystic ovarian syndrome
What are the top hospitals conducting polycystic ovarian syndrome research?
In the realm of polycystic ovarian syndrome (PCOS) clinical trials, the University of Virginia takes center stage. Based in Charlottesville, this institution houses multiple facilities that are actively involved in groundbreaking research for PCOS. The main campus not only conducts four ongoing trials but also has a commendable history with seven completed studies dedicated to understanding and treating this complex condition. Their commitment to PCOS research dates back to their first recorded trial in 2000.
Another standout facility within the University of Virginia is the Center for Research in Reproduction, which also operates in Charlottesville. With three active PCOS trials and eight completed ones, they have been making significant contributions since initiating their first study on this syndrome in 2006. In conjunction with this center, another branch known as the Center for Research in Reproduction collaborates on two ongoing PCOS trials while having accomplished six previous investigations since 2006 as well.
Moreover, the university's Clinical Research Unit has joined forces by conducting two current trials specifically focused on polycystic ovarian syndrome. Although relatively new to PCOS research compared to other institutions, having initiated their first recorded trial only five years ago in 2016, they demonstrate a dedication and determination to contribute valuable insights into managing and treating this condition.
On a different note geographically speaking," Boston stands out amidst these remarkable medical endeavors." Massachusetts General Hospital is recognized even outside its location scope due to its exceptional reputation when it comes down participation related exclusively towards addressing Polycystic Ovarian Syndrome . Currently running one clinical test while being credited previously through undertaking three sophisticated investigatory practices regarding such conditions from an earlier decade starting point:in particular ,the year identified as 2009
These hospitals serve as beacons of hope for those affected by polycystic ovarian syndrome and signify progress made towards understanding and improving treatment options for individuals dealing with this challenging disorder.
Which are the best cities for polycystic ovarian syndrome clinical trials?
Charlottesville, Virginia emerges as the hub for polycystic ovarian syndrome (PCOS) clinical trials, boasting 11 ongoing studies. These trials investigate potential treatments such as Metformin, Spironolactone, and Dexamethasone. San Francisco, California; Chicago, Illinois; and Davenport, Iowa also contribute to PCOS research with two active trials each. In San Francisco and Chicago, subjects are being studied in relation to CPAP Group intervention and Vigorous Exercise respectively. Meanwhile, in Davenport, Letrozole is a focus of investigation. Finally, Boston hosts one active trial exploring the effects of kisspeptin and GnRH on PCOS treatment options. Together these cities offer opportunities for individuals affected by PCOS to participate in cutting-edge research aimed at advancing care for this condition
Which are the top treatments for polycystic ovarian syndrome being explored in clinical trials?
Polycystic ovarian syndrome (PCOS) is a condition that researchers are actively exploring in clinical trials, seeking effective treatment options. Metformin has emerged as a leading contender, currently being tested in three active PCOS trials. With a history dating back to 2000, it has played a role in 76 all-time PCOS trials, highlighting its long-standing significance. Another potential option gaining attention is spironolactone, involved in two ongoing PCOS studies and with five all-time trials since its introduction to the field in 2016. The pursuit of breakthrough treatments for PCOS remains steadfast as scientists strive to improve the lives of those affected by this complex hormonal disorder.
What are the most recent clinical trials for polycystic ovarian syndrome?
Exciting advancements in clinical trials offer hope for individuals with polycystic ovarian syndrome (PCOS). Among the latest studies is one exploring the effectiveness of kisspeptin and GnRH treatment, which has entered Phase 1. Additionally, a Phase 4 trial focusing on Letrozole's potential as a therapy for PCOS showcases promising results. Other ongoing trials include investigations into the Etonogestrel/ethinyl estradiol vaginal ring and Inositol, both demonstrating potential benefits in managing symptoms associated with PCOS. These innovative approaches provide encouragement to those affected by this condition, offering prospects for improved treatment options moving forward.
What polycystic ovarian syndrome clinical trials were recently completed?
Recently concluded clinical trials have made significant strides in the field of polycystic ovarian syndrome (PCOS) research. In December 2017, a trial led by Yale University investigated the effectiveness of a GnRH antagonist in managing this complex condition. Similarly, the University of Colorado, Denver conducted a study on Byetta 5Mcg Pen Injection which was completed in August 2014 to explore potential therapeutic options for PCOS. Finally, in April 2013, researchers at the University of California, Los Angeles tested Flutamide as a potential treatment modality for PCOS patients. These clinical trials serve as crucial stepping stones towards better understanding and treating polycystic ovarian syndrome.