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E-Selectin Antagonist

Uproleselan for COVID-19

Phase 1 & 2
Waitlist Available
Research Sponsored by Lena Napolitano, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during hospitalization; hospital stay ranged from 2 to 10 days
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing uproleselan, a drug that may help people with severe COVID-19 pneumonia recover faster and avoid worsening lung problems. It works by blocking a protein that causes inflammation and lung damage.

Eligible Conditions
  • COVID-19

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during hospitalization; hospital stay ranged from 2 to 10 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and during hospitalization; hospital stay ranged from 2 to 10 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Safety of Uproleselan - as Measured by Serious Adverse Events
Safety of Uproleselan- as Measured by Frequency of Serious Adverse Events
Secondary study objectives
Actual Duration of Hospitalization
Actual Duration of ICU Care
All-cause Mortality
+9 more

Side effects data

From 2022 Phase 2 trial • 51 Patients • NCT04682405
100%
Neutrophil count decreased
100%
Platelet count decreased
100%
Diarrhea
100%
White blood cell decreased
100%
Hypocalcemia
96%
Nausea
96%
Anemia
92%
Lymphocyte count decreased
88%
Fatigue
88%
Hypoalbuminemia
81%
Abdominal Pain
81%
INR increased
81%
Hypophosphatemia
69%
Hypokalemia
65%
Vomiting
50%
Esophageal Pain
50%
Mucositis oral
38%
Esophagitis
35%
Constipation
35%
Enterocolitis
35%
Fever
35%
Malaise
31%
Hyponatremia
31%
Hypotension
27%
Thrush
23%
Gastritis
23%
Dizziness
19%
Hemorrhoids
19%
Back Pain
15%
Edema Limbs
15%
Anorexia
15%
Proctitis
12%
Skin Infection
12%
Activated partial thromboplastin time prolonged
12%
Gastroesophageal Reflux Disease
12%
Eye Disorders - other
12%
Infections and Infestations - other
12%
Enterocolitis Infectious
12%
Alanine aminotransferase increased
12%
Blood bilirubin increased
12%
Dehydration
12%
Hyperglycemia
12%
Musculoskeletal and Connective Tissue Disorder - other
8%
Bruising
8%
Pain in Extremity
8%
Flatulence
8%
Creatinine increased
8%
Aspartate aminotransferase increased
8%
Generalized Muscle Weakness
8%
Skin and Subcutaneous Tissue Disorders - other
8%
Wheezing
8%
Periorbital Edema
8%
Febrile neutropenia
8%
Bloating
8%
Infusion Site Extravasation
8%
Hypernatremia
8%
Hyperphosphatemia
8%
Hypoglycemia
8%
Headache
8%
Peripheral Sensory Neuropathy
8%
Anxiety
8%
Dyspnea
4%
Respiratory, Thoracic, and Mediastinal Disorders - other
4%
Sepsis
4%
Fall
4%
Neoplasms benign, malignant, and unspecified (incl cysts and polyps) - other
4%
Papulopustular Rash
4%
Dysphagia
4%
Hypertension
4%
Facial Pain
4%
Urinary Tract Infection
4%
Alkaline phosphatase increased
4%
Sinusitis
4%
Vision Decreased
4%
Bacteremia
4%
Lung Infection
4%
Sinus Tachycardia
4%
Adrenal Insufficiency
4%
Dry Mouth
4%
Blurred Vision
4%
Extraocular Muscle Paresis
4%
Localized Edema
4%
Chills
4%
Toothache
4%
Generalized Edema
4%
Non-cardiac Chest Pain
4%
Otitis Externa
4%
Hyperkalemia
4%
Muscle Cramp
4%
Nervous System Disorders - other
4%
Encephalopathy
4%
Lethargy
4%
Psychiatric Disorders - other
4%
Testicular Pain
4%
Confusion
4%
Delirium
4%
Hallucinations
4%
Insomnia
4%
Restlessness
4%
Dysuria
4%
Hematuria
4%
Allergic Rhinitis
4%
Cough
4%
Nasal Congestion
4%
Pulmonary Edema
100%
80%
60%
40%
20%
0%
Study treatment Arm
Uproleselan + Standard of Care Melphalan
Placebo + Standard of Care Melphalan

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: UproleselanExperimental Treatment1 Intervention
Uproleselan injection is a sterile solution for IV administration, supplied in single-dose vials at a concentration of 50 mg/mL.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Uproleselan
2021
Completed Phase 2
~100

Find a Location

Who is running the clinical trial?

Lena Napolitano, MDLead Sponsor
GlycoMimetics IncorporatedIndustry Sponsor
22 Previous Clinical Trials
1,470 Total Patients Enrolled
~1 spots leftby Dec 2025
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