← Back to Search

Cephalosporin Antibiotic

Ceftriaxone for Meniscus Tears (PROPER Trial)

Phase 2
Waitlist Available
Led By Austin V Stone, MD, PhD
Research Sponsored by Austin V Stone
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-operative, 2 months post-operative

Summary

This trial is testing if an antibiotic called ceftriaxone can reduce pain and the need for strong painkillers in patients with cartilage or meniscal injuries. Ceftriaxone works by lowering inflammation, which helps to reduce pain. Ceftriaxone has been shown to be effective in reducing pain and inflammation in various types of surgeries.

Eligible Conditions
  • Cartilage Injury
  • Meniscal Injury
  • Meniscus Tears

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-operative, 2 months post-operative
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-operative, 2 months post-operative for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in RU SATED Score
Change in Visual Analog Scale (VAS) Pain Score
Post-operative Narcotic Use

Side effects data

From 2021 Phase 4 trial • 32 Patients • NCT04218695
12%
Decompensated cirrhosis
6%
Hepatic Failure
6%
Rectus sheath hematoma
6%
Nausea
6%
Pruritus with rash
6%
Possible gastrointestinal bleed
6%
hyperkalemia
6%
UTI
6%
Hepatic Encephalopathy
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ExperimentalExperimental Treatment1 Intervention
The experimental group will receive a single intravenous dose of 1 g of ceftriaxone immediately postoperative in the operating room.
Group II: PlaceboPlacebo Group1 Intervention
The placebo group will receive a single intravenous dose of 1% lidocaine and saline immediately postoperative in the operating room.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ceftriaxone
2019
Completed Phase 4
~9340

Find a Location

Who is running the clinical trial?

Austin V StoneLead Sponsor
4 Previous Clinical Trials
69 Total Patients Enrolled
2 Trials studying Meniscus Tears
68 Patients Enrolled for Meniscus Tears
Austin V Stone, MD, PhDPrincipal InvestigatorUniversity of Kentucky

Media Library

Ceftriaxone (Cephalosporin Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT05149287 — Phase 2
Meniscus Tears Research Study Groups: Experimental, Placebo
Meniscus Tears Clinical Trial 2023: Ceftriaxone Highlights & Side Effects. Trial Name: NCT05149287 — Phase 2
Ceftriaxone (Cephalosporin Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05149287 — Phase 2
~1 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top