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Coenzyme Q10
Ubiquinone vs. Ubiquinol for In Vitro Fertilization
Phase 2
Waitlist Available
Research Sponsored by Trio Fertility
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Have a body mass index (BMI) ≥17.5 and ≤38 kg/m2
Women age >37 and <43 years undergoing their first in vitro fertilization (IVF) cycle
Must not have
Has Asherman's syndrome (untreated) or endometrial polyps that have not been resected
One or both ovaries not accessible for oocyte retrieval
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights
No Placebo-Only Group
Summary
"This trial aims to see if a form of ubiquinol can help older women have better reproductive outcomes with a lower dose compared to the current standard treatment using ubiquinone."
Who is the study for?
Women aged >37 and <43 undergoing their first IVF cycle, with a history of infertility but normal reproductive health markers. They must have a BMI between 17.5 and 38, non-smokers, no significant medical conditions or ovarian issues that would affect egg retrieval, and partners with suitable semen for IVF.
What is being tested?
The trial is testing if ubiquinol at a lower dose improves reproductive outcomes in older women compared to the standard treatment with ubiquinone during IVF cycles.
What are the potential side effects?
Specific side effects are not listed for this trial; however, common side effects from oral supplements like ubiquinone and ubiquinol may include digestive discomfort or allergic reactions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My BMI is between 17.5 and 38.
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I am a woman between 37 and 43 years old trying IVF for the first time.
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My pelvic ultrasound showed no large cysts.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have untreated Asherman's syndrome or unremoved endometrial polyps.
Select...
My ovaries cannot be used for egg collection.
Select...
My cancer is in the ovary, breast, uterus, pituitary, or hypothalamus.
Select...
I have had surgery on my ovary, such as for a cyst or tumor.
Select...
I have fluid in my fallopian tubes that shows on an ultrasound or special X-ray.
Select...
I have fibroids larger than 3 cm or any size if they are submucosal.
Select...
I have a history of serious health conditions like epilepsy or diabetes that required treatment in the last 3 years.
Select...
I currently smoke 5 or more cigarettes daily.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, an average of 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Fertilized oocyte percentage
Secondary study objectives
MII oocyte percentage
Protein structural change
Reproductive outcome
+1 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: coQ10BExperimental Treatment1 Intervention
Eligible subjects will be receiving ubiquinol 100 mg prior to their IVF cycle.
Group II: coQ10 AExperimental Treatment1 Intervention
Eligible subjects will be receiving ubiquinone 200 mg prior to their in vitro fertilization (IVF) cycle.
Group III: ControlActive Control1 Intervention
Subjects are not receiving coQ10 supplementation.
Find a Location
Who is running the clinical trial?
Trio FertilityLead Sponsor
2 Previous Clinical Trials
130 Total Patients Enrolled
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