TLPO Vaccine for Cancer
Trial Summary
What is the purpose of this trial?
This trial tests a new cancer vaccine made from a patient's own tumor cells. It targets patients with solid tumors and aims to help their immune system fight the cancer. The vaccine works by teaching the immune system to recognize and attack cancer cells.
Will I have to stop taking my current medications?
The trial protocol does not specify if you must stop taking your current medications. However, you cannot take steroids, immunosuppressive therapy, or cytotoxic chemotherapy within 30 days of enrolling in the trial.
What data supports the effectiveness of the TLPO Vaccine treatment for cancer?
The TLPO Vaccine, which uses tumor lysate (a mixture of proteins from a patient's own tumor) to stimulate the immune system, has shown promise in preventing melanoma recurrence in high-risk patients. Studies have indicated that similar vaccines, like the TLPLDC, are safe and can improve survival rates when combined with standard cancer treatments.12345
Is the TLPO Vaccine safe for humans?
How is the TLPO Vaccine treatment different from other cancer treatments?
Eligibility Criteria
This trial is for individuals with various types of solid tumor cancers, including those that have spread (metastasized). Participants must meet certain health standards but specific inclusion criteria are not listed. People who do not meet the study's requirements or have conditions that might interfere with the vaccine's effects will be excluded.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Tissue Procurement
Eligible patients undergo surgical resection or core needle biopsy for tissue procurement
Vaccine Preparation
Tumor samples are shipped for vaccine preparation and returned as TLPO vaccine
Vaccination
Participants receive intradermal injections of TLPO vaccine at 0, 1, and 2 months, followed by boosters at 6, 9, and 12 months
Follow-up
Participants are monitored for safety, disease progression, and immune response
Treatment Details
Interventions
- Autologous TLPO Vaccine (Cancer Vaccine)