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HDAC Inhibitor

Arm I for Sarcoma

Phase 1 & 2
Waitlist Available
Research Sponsored by National Cancer Institute (NCI)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

Phase I/II trial to study the effectiveness of BMS-275291 in treating patients who have HIV-related Kaposi's sarcoma. Drugs such as BMS-275291 may stop the growth of Kaposi's sarcoma by stopping blood flow to the tumor.

Eligible Conditions
  • Sarcoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

1Treatment groups
Experimental Treatment
Group I: Arm IExperimental Treatment1 Intervention
Patients receive oral BMS-275291 1-2 times daily. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 6 patients receive escalating doses of BMS-275291 until the recommended phase II dose (RPTD) is determined. The RPTD is the dose at which no more than 1 of 6 patients experiences dose-limiting toxicity and more than 1 of 6 patients experiences clinical response or at least 5 of 6 patients demonstrate biologic activity. An additional 29 patients are treated at the RPTD.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rebimastat
Not yet FDA approved

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)Lead Sponsor
13,857 Previous Clinical Trials
41,006,645 Total Patients Enrolled
459 Trials studying Sarcoma
234,347 Patients Enrolled for Sarcoma
Jamie Hayden Von Roenn, MDStudy ChairRobert H. Lurie Cancer Center
3 Previous Clinical Trials
33 Total Patients Enrolled
1 Trials studying Sarcoma
33 Patients Enrolled for Sarcoma
~2 spots leftby Sep 2025
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