LOXO-338 for Blood Cancers
This trial is testing a new drug, LOXO-338, to treat advanced blood cancer in patients who haven't responded to standard treatments. If effective alone, it will also be tested with another drug, pirtobrutinib, to see if the combination works better.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Acalabrutinib + Chemotherapy for Waldenstrom's Macroglobulinemia
This trial tests a combination of two established drugs and one new drug in untreated patients with a specific type of blood cancer. The treatment works by killing cancer cells, boosting the immune system, and blocking growth signals.
CAR T-cell Therapy
CLBR001 CAR-T for Non-Hodgkin's Lymphoma
This trial involves monitoring patients who received a special cancer treatment using their own modified immune cells. These patients are followed for an extended period to check for safety and effectiveness. The treatment works by reprogramming the patient's immune cells to better fight cancer and has shown promising results.
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Trials for WM Patients
Antibiotic
Rifaximin for Monoclonal Gammopathy
This trial studies how well rifaximin, an oral antibiotic, works in treating patients with monoclonal gammopathy. It aims to reduce abnormal blood proteins or cells by killing intestinal bacteria. Rifaximin has been used successfully for CDI treatment but lacks United States Food and Drug Administration approval for this indication.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Oral LOXO-305 for Chronic Lymphocytic Leukemia
This trial is testing pirtobrutinib, a tablet taken by mouth, in patients with certain types of blood cancers who haven't responded to or can't tolerate usual treatments. The medication works by blocking a protein that cancer cells need to grow. The study aims to find the best dose and see how well it works.
Enzyme Inhibitor
Ibrutinib + Ixazomib for Waldenstrom's Macroglobulinemia
This trial looks at the side effects of two drugs, ibrutinib and ixazomib, when given together to treat Waldenstrom macroglobulinemia. Enzyme inhibitors, such as ibrutinib and ixazomib, may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Stem Cell Transplant + Chemotherapy for Leukemia and Lymphoma
This trial is studying how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant.
BTK Inhibitor
Nemtabrutinib for Blood Cancers
This trial is testing a new pill called nemtabrutinib for patients with blood cancers that have returned or didn't respond to other treatments. The goal is to find a safe and effective dose of the drug. Nemtabrutinib is a new drug being tested for blood cancers, designed to reduce adverse effects.
Trials for LPL Patients
Antibiotic
Rifaximin for Monoclonal Gammopathy
This trial studies how well rifaximin, an oral antibiotic, works in treating patients with monoclonal gammopathy. It aims to reduce abnormal blood proteins or cells by killing intestinal bacteria. Rifaximin has been used successfully for CDI treatment but lacks United States Food and Drug Administration approval for this indication.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Oral LOXO-305 for Chronic Lymphocytic Leukemia
This trial is testing pirtobrutinib, a tablet taken by mouth, in patients with certain types of blood cancers who haven't responded to or can't tolerate usual treatments. The medication works by blocking a protein that cancer cells need to grow. The study aims to find the best dose and see how well it works.
Enzyme Inhibitor
Ibrutinib + Ixazomib for Waldenstrom's Macroglobulinemia
This trial looks at the side effects of two drugs, ibrutinib and ixazomib, when given together to treat Waldenstrom macroglobulinemia. Enzyme inhibitors, such as ibrutinib and ixazomib, may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Radioisotope Therapy
Iopofosine for Waldenstrom Macroglobulinemia
This trial is testing a special radiation treatment called iopofosine I 131 in patients with hard-to-treat B-cell cancers. These patients have not responded well to other treatments. The treatment works by using a radioactive substance that targets and kills cancer cells.
Trials With No Placebo
Antibiotic
Rifaximin for Monoclonal Gammopathy
This trial studies how well rifaximin, an oral antibiotic, works in treating patients with monoclonal gammopathy. It aims to reduce abnormal blood proteins or cells by killing intestinal bacteria. Rifaximin has been used successfully for CDI treatment but lacks United States Food and Drug Administration approval for this indication.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Oral LOXO-305 for Chronic Lymphocytic Leukemia
This trial is testing pirtobrutinib, a tablet taken by mouth, in patients with certain types of blood cancers who haven't responded to or can't tolerate usual treatments. The medication works by blocking a protein that cancer cells need to grow. The study aims to find the best dose and see how well it works.
Enzyme Inhibitor
Ibrutinib + Ixazomib for Waldenstrom's Macroglobulinemia
This trial looks at the side effects of two drugs, ibrutinib and ixazomib, when given together to treat Waldenstrom macroglobulinemia. Enzyme inhibitors, such as ibrutinib and ixazomib, may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Stem Cell Transplant + Chemotherapy for Leukemia and Lymphoma
This trial is studying how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant.
BTK Inhibitor
Nemtabrutinib for Blood Cancers
This trial is testing a new pill called nemtabrutinib for patients with blood cancers that have returned or didn't respond to other treatments. The goal is to find a safe and effective dose of the drug. Nemtabrutinib is a new drug being tested for blood cancers, designed to reduce adverse effects.
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Frequently Asked Questions
Introduction to waldenstrom macroglobulinemia
What are the top hospitals conducting waldenstrom macroglobulinemia research?
In the realm of cutting-edge clinical trials for Waldenstrom Macroglobulinemia, several esteemed hospitals stand out as beacons of hope. The Dana Farber Cancer Institute in Boston leads the charge with nine ongoing trials dedicated to this rare blood cancer, along with a significant history of 18 completed studies. Since initiating their first trial in 2011, this renowned institution has been at the forefront of advancing our understanding and treatment options for Waldenstrom Macroglobulinemia.
Not far behind is the Memorial Sloan Kettering Cancer Center in New york, which currently has six active trials focused on this condition. With an impressive track record consisting of 11 previous studies dating back to their inaugural trial in 2005, they have consistently contributed to the field's progress and patient care.
Meanwhile, the Medical College of Wisconsin in Milwaukee actively conducts five Waldenstrom Macroglobulinemia clinical trials while having completed six previously since embarking on its first investigation into this disease in 2011. Similarly committed to pushing boundaries is Seattle's Fred Hutch/University of Washington Cancer Consortium where researchers are also engaged in five ongoing trials for Waldenstrom Macroglobulinemia after successfully conducting thirteen earlier investigations starting from as early as 2003.
Lastly but certainly not least is The University of Texas MD Anderson Cancer Center situated amidst Houston's medical landscape.With four active waldenstrom macroglobinulia cases under rigorous study,and holding pride among limited numbers,four prior experiments adds feathers bringing attention through meticulous work proposed by them only from around ten years ago-2011.While relatively smaller numbers may indicate that more research opportunities lie ahead,the collective efforts made by these top hospitals underline dedication towards improving outcomes for patients battling Waldenstrom Macroglobulinemia worldwide
Which are the best cities for waldenstrom macroglobulinemia clinical trials?
When it comes to clinical trials for Waldenstrom macroglobulinemia, several cities have emerged as leading hubs of research and innovation. New york, with its 27 active trials, explores treatments such as BGB-16673, Pirtobrutinib, and Oral Azacitidine. Boston closely follows with 22 ongoing studies investigating combinations like PIRTOBRUTINIB + VENETOCLAX and Loncastuximab Tesirine. Houston also plays a significant role in the field with 19 active trials focusing on therapies such as Zilovertamab vedotin and BGB-16673. Finally, Seattle contributes to the advancement of treatment options through 17 active trials examining interventions like Pirtobrutinib and Allogeneic Hematopoietic Stem Cell Transplantation. These cities host a wide array of clinical trials offering hope to individuals living with Waldenstrom macroglobulinemia by paving the way for novel therapeutic approaches.
Which are the top treatments for waldenstrom macroglobulinemia being explored in clinical trials?
Waldenstrom macroglobulinemia, a rare form of blood cancer, is pushing the boundaries of medical research with its ongoing clinical trials. Acalabrutinib takes the lead, currently being explored in four active trials dedicated to combating this challenging disease since 2015. Joining the race are CLBR001 and SWI019, both showing promise with two active trials each since their listing in 2020. Nemtabrutinib also makes waves with two ongoing trials after making its debut on the scene in 2017. Last but not least is melphalan, participating in two current investigations and boasting three all-time clinical trial involvements since its introduction back in 2010. Together, these treatments bring hope for those battling Waldenstrom macroglobulinemia towards a brighter future.
What are the most recent clinical trials for waldenstrom macroglobulinemia?
Exciting developments have emerged in recent clinical trials for Waldenstrom macroglobulinemia, offering hope and potential treatment options. One such trial focuses on dose escalation, aiming to determine the optimal dosage for improved outcomes in patients with this condition. Another study explores the combination of Pirtobrutinib and Venetoclax as a potential therapeutic approach for Waldenstrom macroglobulinemia. Additionally, there is ongoing research into brexucabtagene autoleucel, investigating its efficacy specifically in relapsed or refractory hairy cell leukemia cases under the umbrella of Waldenstrom macroglobulinemia. These advances bring us closer to more effective treatments for individuals affected by this rare blood cancer.
What waldenstrom macroglobulinemia clinical trials were recently completed?
Recent clinical trials in the field of Waldenstrom macroglobulinemia have yielded valuable insights and advancements. Notably, X4 Pharmaceuticals completed a trial for Mavorixafor in April 2020, showcasing its potential as a treatment option. Additionally, the University of Rochester successfully conducted a trial testing the efficacy of the Shingrix vaccine in February 2019. Several other trials were also concluded earlier to explore various treatments such as CDX-1140 (December 2017), Umbralisib (November 2017), Daratumumab (November 2017), Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells (October 2017), BGB-3111 (January 2017). These recent studies underline the ongoing efforts to enhance therapeutic options for individuals living with Waldenstrom macroglobulinemia.