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Esophageal Manometry

Esophageal Manometry During Recovery From Anesthesia: Pilot Study (EMAP Trial)

N/A
Waitlist Available
Led By Stanley Rogers, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during the last 15 minutes of general anesthesia use
Awards & highlights
No Placebo-Only Group

Summary

1. An intact pharyngoesophageal reflex is essential to protect the upper airway from aspiration of either mouth contents or regurgitated gastric refluxate. This reflex is essential at protecting the airway in all patients. 2. In patients, while under general anesthesia, it is postulated that an identifiable upper esophageal sphincter and esophageal peristalsis are not present. 3. With the cessation of general anesthetics, accompanied by the reversal of nerve block, normal pharyngoesophageal peristaltic activity correlates with awakening the patient from anesthesia. This would be identified by the performance of esophageal manometry. 4. A return of normal verbally stimulated pharyngoesophageal swallowing sequence accurately identifies a safe time to remove endotracheal tubes and/or reverse anesthesia. This verbally stimulated swallowing sequence correlated precisely with the return of objective pharyngoesophageal function.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during the last 15 minutes of general anesthesia use
This trial's timeline: 3 weeks for screening, Varies for treatment, and during the last 15 minutes of general anesthesia use for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Total time of the return of normal pharyngoesophageal function
Secondary study objectives
Number of participants with normal pharyngoesophageal function.

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Manometry DeviceExperimental Treatment1 Intervention
During the last 10 minutes of subjects "waking up" from anesthesia, the motility procedure will be performed.

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Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,593 Previous Clinical Trials
14,901,762 Total Patients Enrolled
Stanley Rogers, MDPrincipal InvestigatorUniversity of California, San Francisco
~1 spots leftby Dec 2025
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