Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
(CLASS-D Trial)

Recruiting in Palo Alto (17 mi)

Overseen byBen J Palanca, MD PhD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Washington University School of Medicine

No Placebo Group

Trial Summary

What is the purpose of this trial?Prospective within-subject study of dexmedetomidine sedation paired with CLAS conditions in repeated blocks. Intervention will consist of CLAS in-phase with EEG slow waves. Anti-phase stimulation will serve as an active control while sham stimulation will serve as a passive control.

Eligibility Criteria

Inclusion Criteria

Healthy volunteers (American Society of Anesthesiologists Physical Status 1-2).

Age 18-40 years

Exclusion Criteria

You have a medical condition that affects your sleep.

You have a body mass index (BMI) greater than 30.

You use recreational drugs or nicotine.

+7 more

Participant Groups

1Treatment groups

Experimental Treatment

Group I: CLASS-D CohortExperimental Treatment8 Interventions

Within-subject crossover cohort with intervention, acoustic stimulation delivered in phase with the anticipated trough of EEG slow wave oscillation, and 0 dB stimulation.