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Azole Antifungal

Opelconazole for Pulmonary Aspergillosis

Phase 2
Waitlist Available
Research Sponsored by Pulmocide Ltd
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a medication called opelconazole to prevent lung infections caused by Aspergillus fungus in people who have had a lung transplant. The study will last for several months, followed by a safety check. Opelconazole works by stopping the fungus from growing in the lungs, helping to prevent serious infections.

Eligible Conditions
  • Pulmonary Aspergillosis
  • Invasive Aspergillosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: OpelconazoleExperimental Treatment1 Intervention
14.8 mg opelconazole administered twice daily for 12 weeks
Group II: Standard of Care (SoC)Active Control1 Intervention
Mold-active SoC prophylaxis/pre-emptive therapy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Opelconazole
2021
Completed Phase 2
~110

Find a Location

Who is running the clinical trial?

Pulmocide LtdLead Sponsor
9 Previous Clinical Trials
423 Total Patients Enrolled
1 Trials studying Pulmonary Aspergillosis
123 Patients Enrolled for Pulmonary Aspergillosis
Vice President Clinical DevelopmentStudy DirectorPulmocide Ltd
1 Previous Clinical Trials
100 Total Patients Enrolled

Media Library

PC945 (Azole Antifungal) Clinical Trial Eligibility Overview. Trial Name: NCT05037851 — Phase 2
Pulmonary Aspergillosis Research Study Groups: Opelconazole, Standard of Care (SoC)
Pulmonary Aspergillosis Clinical Trial 2023: PC945 Highlights & Side Effects. Trial Name: NCT05037851 — Phase 2
PC945 (Azole Antifungal) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05037851 — Phase 2
~25 spots leftby Nov 2025
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