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Endoplasmic Reticulum Stress Relieving Agent

Taurourodeoxycholic Acid (TUDCA) for Type 1 Diabetes

Phase 2
Waitlist Available
Led By Rudolph Leibel, MD
Research Sponsored by Robin Goland, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights
All Individual Drugs Already Approved

Summary

This trial tests TUDCA, a medication that reduces cell stress, on patients with type 1 diabetes. The aim is to help insulin-producing cells survive and function better, potentially slowing down or preventing the disease's progression.

Eligible Conditions
  • Type 1 Diabetes

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
C-peptide measurement as reflection of insulin secretion
Secondary study objectives
Endoplasmic reticulum stress
liver function tests

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Taurourodeoxycholic Acid (TUDCA)Experimental Treatment1 Intervention
TUDCA 1750 mg/day x 12 months
Group II: Sugar pill (placebo)Placebo Group1 Intervention
Placebo at same dose, frequency, and duration as experimental treatment

Find a Location

Who is running the clinical trial?

Juvenile Diabetes Research FoundationOTHER
234 Previous Clinical Trials
142,061 Total Patients Enrolled
Robin Goland, MDLead Sponsor
Rudolph Leibel, MDPrincipal InvestigatorColumbia University
~2 spots leftby Nov 2025
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