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Hormone Therapy

Estrogen Modulation for Menopause Mood and Cognition

Phase 2
Waitlist Available
Research Sponsored by National Center for Research Resources (NCRR)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Postmenopausal
Not on hormone replacement therapy (HRT) or more than 1 year post HRT
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will study the effects of estrogen on women's brain chemistry, specifically how it affects their mood in response to dietary changes.

Who is the study for?
This trial is for healthy, non-smoking postmenopausal women aged 50-60 and those over 70. Participants must have a BMI under 30, not be on hormone replacement therapy (HRT) or more than a year past HRT, have had a normal mammogram in the last year, and cannot have surgically-induced menopause or cardiovascular disease.
What is being tested?
The study tests if estrogen can affect mood and brain chemistry changes caused by diet in postmenopausal women. Women will take either estrogen or placebo for three months before undergoing dietary challenges to alter neurotransmitters like serotonin.
What are the potential side effects?
While specific side effects are not listed here, generally estrogen treatment may include risks such as headaches, breast tenderness, nausea, mood swings, and blood clotting issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have gone through menopause.
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I am not currently on hormone replacement therapy and have not been for over a year.
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I have not had surgery to remove my ovaries.
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I only have mild high blood pressure, no other heart conditions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Find a Location

Who is running the clinical trial?

National Center for Research Resources (NCRR)Lead Sponsor
539 Previous Clinical Trials
317,102 Total Patients Enrolled
2 Trials studying Menopause
15 Patients Enrolled for Menopause

Media Library

Estrogen (Hormone Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT00005768 — Phase 2
Menopause Research Study Groups:
Menopause Clinical Trial 2023: Estrogen Highlights & Side Effects. Trial Name: NCT00005768 — Phase 2
Estrogen (Hormone Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00005768 — Phase 2
~233 spots leftby Nov 2025
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