Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 3

Waitlist Available

Sponsor: Butler Hospital

No Placebo Group

Pivotal Trial (Near Approval)

Prior Safety Data

Trial Summary

What is the purpose of this trial?The purpose of this study is to test the effects of non-invasive neuromodulation, transcranial magnetic stimulation on brain function in individuals with obsessive-compulsive disorder (OCD). This study is focused on the mechanism(s) by which brain stimulation might change the functioning of regions implicated in OCD, and thereby inform possible future therapeutic uses.

Eligibility Criteria

This trial is for adults aged 18-70 with a primary diagnosis of OCD and moderate to severe symptoms. Participants must have stable mental health treatment, if any, for at least six weeks prior and be able to understand English. Exclusions include pregnancy, metal implants incompatible with MRI or TMS, acute suicidality, certain medical conditions like epilepsy or significant neurological issues, recent substance abuse, psychotic symptoms, and specific medication use.

Inclusion Criteria

Current primary OCD diagnosis and current Y-BOCS total score of ≥16

Ongoing psychotherapy allowed if already established for three months or more before study entry

18-70 years of age

+2 more

Exclusion Criteria

Visual disturbance (<20/40 Snellen visual acuity, corrected)

You are currently experiencing thoughts of suicide.

You have a disease that affects your whole body, like an ongoing condition related to your metabolism, hormones, inflammation, blood vessels, or immune system.

+10 more

Participant Groups

The study tests how transcranial magnetic stimulation (TMS), a non-invasive brain modulation technique affects brain function in people with OCD. It aims to understand the changes in brain regions involved in OCD that could lead to future therapeutic applications.

1Treatment groups

Experimental Treatment

Group I: Transcranial Magnetic StimulationExperimental Treatment1 Intervention

Transcranial Magnetic Stimulation applied over the pre-supplementary motor area (pSMA), for ten sessions, Monday through Friday, over the course of two weeks.