Exercise Incentives + Corticosteroid Injections for Osteoarthritis

(MOVE-OK Trial)

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen by Joshua Baker, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 3

Waitlist Available

Sponsor: VA Office of Research and Development

No Placebo Group

Pivotal Trial (Near Approval)

Prior Safety Data

Trial Summary

What is the purpose of this trial?

Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement. Importantly, low levels of physical activity in patients with knee problems might worsen pain and disability. This study aims to determine the feasibility of using methods to change behavior that use social incentives and promote physical activity through playing games and interacting with a web-based platform. The study will also evaluate an important and widely used treatment, namely corticosteroid injections. Participants will be randomized into one of 4 arms and will receive a different combination of social incentives and injections. The study will evaluate which approach is most effective at promoting physical activity and reducing pain and disability.

Eligibility Criteria

This trial is for Veterans with chronic knee osteoarthritis who have had joint injections before, want to increase their physical activity, and can walk at least half a mile per day. It's not for those without a smartphone, in acute pain, with conditions that make exercise unsafe, or with knee hardware that prevents injections.

Inclusion Criteria

Veterans in VA Rheumatology or Orthopedic clinics

I need an injection in my joint.

I have long-term knee arthritis.

Exclusion Criteria

I have hardware in my joint or a reason I can't have joint injections.

Comorbid condition that precludes safe exercise

Lack of smart phone

Participant Groups

The study tests if social incentives and gamification can boost exercise among these patients versus corticosteroid injections alone. Participants are randomly placed into one of four groups to see which combination best increases physical activity and reduces pain and disability.

Group I: Social Incentives and Gamification, Corticosteroid BA Experimental Treatment 2 Interventions

Participants will receive a support person and be able to interact with a web-based platform to progress through levels based on their achievement of step goals. The participants will receive injections in B-A order (lidocaine only, then corticosteroids)

Group II: Social Incentives and Gamification, Corticosteroid AB Experimental Treatment 2 Interventions

Participants will receive a support person and be able to interact with a web-based platform to progress through levels based on their achievement of step goals. The participants will receive injections in A-B order (corticosteroids, then lidocaine only)

Group III: No Incentive, Corticosteroid AB Active Control 2 Interventions

Participants will only receive reminders to sync their activity monitor. The participants will receive injections in A-B order (corticosteroids, then lidocaine only)

Group IV: No Incentive, Corticosteroid BA Active Control 2 Interventions

Participants will only receive reminders to sync their activity monitor. The participants will receive injections in B-A order (lidocaine only, then corticosteroids)

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE Omaha, NE

VA Puget Sound Health Care System Seattle Division, Seattle, WA Seattle, WA

Washington DC VA Medical Center, Washington, DC Washington, United States

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA Philadelphia, PA

Who Is Running the Clinical Trial?

VA Office of Research and Development Lead Sponsor

References