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Exercise Incentives + Corticosteroid Injections for Osteoarthritis (MOVE-OK Trial)

Phase 3
Recruiting
Led By Joshua F. Baker, MD MSCE
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Chronic knee osteoarthritis
Patient is able to walk 1/2 mile per day
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured every 4 weeks over 3-10 months (3 for injection intervention and 10 for exercise intervention)
Awards & highlights

MOVE-OK Trial Summary

This trial will study whether social incentives and game-based interaction can help manage knee osteoarthritis pain and disability, as well as whether corticosteroid injections are an effective treatment.

Who is the study for?
This trial is for Veterans with chronic knee osteoarthritis who have had joint injections before, want to increase their physical activity, and can walk at least half a mile per day. It's not for those without a smartphone, in acute pain, with conditions that make exercise unsafe, or with knee hardware that prevents injections.Check my eligibility
What is being tested?
The study tests if social incentives and gamification can boost exercise among these patients versus corticosteroid injections alone. Participants are randomly placed into one of four groups to see which combination best increases physical activity and reduces pain and disability.See study design
What are the potential side effects?
Corticosteroid injections may cause side effects like increased pain at the injection site, infection risk, skin discoloration, allergic reactions or weakening of nearby bones. The behaviorally enhanced exercises should be safe but might lead to overexertion.

MOVE-OK Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have long-term knee arthritis.
Select...
I can walk 1/2 mile every day.
Select...
I have had injections in my joints for pain relief before.

MOVE-OK Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured every 4 weeks over 3-10 months (3 for injection intervention and 10 for exercise intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured every 4 weeks over 3-10 months (3 for injection intervention and 10 for exercise intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Knee Injury and Osteoarthritis Outcome Score (KOOS)
Percent change from baseline in weekly average steps per day
Secondary outcome measures
Change in Knee Injury and Osteoarthritis Outcomes Score (KOOS)
Change in PROMIS Fatigue
Change in PROMIS pain intensity score

MOVE-OK Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Social Incentives and Gamification, Corticosteroid BAExperimental Treatment2 Interventions
Participants will receive a support person and be able to interact with a web-based platform to progress through levels based on their achievement of step goals. The participants will receive injections in B-A order (lidocaine only, then corticosteroids)
Group II: Social Incentives and Gamification, Corticosteroid ABExperimental Treatment2 Interventions
Participants will receive a support person and be able to interact with a web-based platform to progress through levels based on their achievement of step goals. The participants will receive injections in A-B order (corticosteroids, then lidocaine only)
Group III: No Incentive, Corticosteroid ABActive Control2 Interventions
Participants will only receive reminders to sync their activity monitor. The participants will receive injections in A-B order (corticosteroids, then lidocaine only)
Group IV: No Incentive, Corticosteroid BAActive Control2 Interventions
Participants will only receive reminders to sync their activity monitor. The participants will receive injections in B-A order (lidocaine only, then corticosteroids)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Social Incentives and Gamification to Promote Exercise
2019
N/A
~40
Corticosteroid Injection given in A-B order
2019
N/A
~40

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,621 Previous Clinical Trials
3,323,261 Total Patients Enrolled
21 Trials studying Osteoarthritis
3,310 Patients Enrolled for Osteoarthritis
Joshua F. Baker, MD MSCEPrincipal InvestigatorCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
1 Previous Clinical Trials
34 Total Patients Enrolled
1 Trials studying Osteoarthritis
34 Patients Enrolled for Osteoarthritis

Media Library

Social Incentives and Gamification to Promote Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05035810 — Phase 3
Osteoarthritis Research Study Groups: Social Incentives and Gamification, Corticosteroid AB, No Incentive, Corticosteroid AB, Social Incentives and Gamification, Corticosteroid BA, No Incentive, Corticosteroid BA
Osteoarthritis Clinical Trial 2023: Social Incentives and Gamification to Promote Exercise Highlights & Side Effects. Trial Name: NCT05035810 — Phase 3
Social Incentives and Gamification to Promote Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05035810 — Phase 3
Osteoarthritis Patient Testimony for trial: Trial Name: NCT05035810 — Phase 3
~37 spots leftby Nov 2024
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