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Tetracycline Antibiotic

2% Doxycycline Cream in Generic Aquaphor for Hives

Phase 2
Waitlist Available
Led By Rauno O Joks, MD
Research Sponsored by State University of New York - Downstate Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Adult (ages 18-75) outpatients with diagnosis of allergic rhino-conjunctivitis and/or asthma who have previously undergone epicutaneous skin prick testing with detection of at least one allergen positive, and who may or may not have had a serum IgE level done as part of their routine evaluation.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 minutes
Awards & highlights

Summary

Investigators will study the effects of topical doxycycline on cutaneous allergic early and late phase responses by determining allergen skin responses in each subject after a single application to allergen induced allergic swelling of 2% doxycycline in emollient.

Eligible Conditions
  • Hives

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Mean Allergen Induced Wheal Diameter

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: 2% Doxycycline Cream in Generic AquaphorActive Control1 Intervention
2% Doxycycline Cream in Generic Aquaphor will be applied topically twice during the study visit: first for 30 minutes, then for 6 hours duration. Will perform concurrent to Placebo Comparator
Group II: Generic AquaphorPlacebo Group1 Intervention
Generic Aquaphor will be applied topically twice during the study visit: first for 30 minutes, then for 6 hours duration. Will perform concurrent to Active Comparator.

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Who is running the clinical trial?

State University of New York - Downstate Medical CenterLead Sponsor
66 Previous Clinical Trials
12,132 Total Patients Enrolled
Rauno O Joks, MDPrincipal InvestigatorState University of New York - Downstate Medical Center
~4 spots leftby Oct 2025
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