← Back to Search

ACE Inhibitor

ramipril for Coronary Artery Dissection (SAFER-SCAD Trial)

Phase 4
Waitlist Available
Led By Tara Sedlak, MD
Research Sponsored by Cardiology Research UBC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Summary

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the heart (or microcirculation). We want to determine whether commonly used medications for coronary artery disease including statins (for cholesterol) and angiotensin-converting enzyme inhibitors (for blood pressure) reduce chest pain and improve small vessel function in these patients.

Eligible Conditions
  • Coronary Artery Dissection

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Angina frequency domain of the SAQ
Secondary outcome measures
Acute coronary syndrome or hospitalization for angina

Trial Design

2Treatment groups
Experimental Treatment
Group I: Rosuvastatin, placeboExperimental Treatment2 Interventions
rosuvastatin 10-20mg daily or placebo (suggested dose of 10mg for Asians, and 20mg for others)
Group II: Ramipril, placeboExperimental Treatment2 Interventions
ramipril (starting dose of ramipril at 5mg daily titrating up to 10mg daily at 1 week if tolerated) versus placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ramipril
FDA approved
Rosuvastatin
FDA approved
placebo
2010
Completed Phase 4
~6580

Find a Location

Who is running the clinical trial?

Cardiology Research UBCLead Sponsor
15 Previous Clinical Trials
7,129 Total Patients Enrolled
Tara Sedlak, MDPrincipal InvestigatorUniversity of British Columbia
~2 spots leftby Sep 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top