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Trials for Acute Myeloid Leukemia Patients
Anti-tumor antibiotic
Chemotherapy Combination for Leukemia
This trial is testing a combination of drugs to treat patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome. The drugs work in different ways to stop the growth of cancer cells.
Alkylating agents
Cord Blood Transplant + Chemo/Radiation for Leukemia and Lymphoma
This trial is testing whether giving an umbilical cord blood transplant together with chemotherapy and radiation therapy works better than just giving an umbilical cord blood transplant for treating patients with hematologic disease.
Alkylating agents
Chemoradiotherapy + Stem Cell Transplant for Blood Cancers
This trial is giving chemotherapy drugs and HT before a donor stem cell transplant to see if it helps stop the growth of cancer cells and also helps stop the patient's immune system from rejecting the donor's stem cells.
Proteasome Inhibitor
Chemotherapy + Stem Cell Transplant for Multiple Myeloma
This trial is studying the side effects and best dose of bortezomib when given together with fludarabine phosphate and melphalan with or without total marrow irradiation for patients with high-risk stage I or II multiple myeloma.
Alkylating agents
Intensity Modulated Total Marrow Irradiation + Fludarabine Phosphate + Melphalan for Hematologic Cancers
This trial is testing IMTMI to see if it's less toxic and more effective than other types of radiation therapy when given with fludarabine and melphalan to patients with relapsed blood cancer before a stem cell transplant.
Trials for Myelodysplastic Syndrome Patients
Anti-tumor antibiotic
Chemotherapy Combination for Leukemia
This trial is testing a combination of drugs to treat patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome. The drugs work in different ways to stop the growth of cancer cells.
Alkylating agents
Cord Blood Transplant + Chemo/Radiation for Leukemia and Lymphoma
This trial is testing whether giving an umbilical cord blood transplant together with chemotherapy and radiation therapy works better than just giving an umbilical cord blood transplant for treating patients with hematologic disease.
Alkylating agents
Chemoradiotherapy + Stem Cell Transplant for Blood Cancers
This trial is giving chemotherapy drugs and HT before a donor stem cell transplant to see if it helps stop the growth of cancer cells and also helps stop the patient's immune system from rejecting the donor's stem cells.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Ibrutinib + Rituximab for Chronic Lymphocytic Leukemia
This trial is studying ibrutinib and rituximab compared to fludarabine phosphate, cyclophosphamide, and rituximab to see which works better in treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
Phase 3 Trials
Anti-metabolites
5-Fluorouracil Injection for Chalazion
This trial compares different treatments for eyelid lumps called chalazia. The treatments include medicine injections or minor surgery. The goal is to see which method best reduces or removes these lumps. Injections have been used effectively in treating chalazia, showing high success rates in previous studies.
Anti-metabolites
Chemotherapy for Pancreatic Cancer
This trial is studying gemcitabine hydrochloride given with or without erlotinib hydrochloride, followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil, to see how well it works in treating patients with pancreatic cancer that has been removed by surgery.
Bruton's Tyrosine Kinase (BTK) Inhibitor
Ibrutinib + Rituximab for Chronic Lymphocytic Leukemia
This trial is studying ibrutinib and rituximab compared to fludarabine phosphate, cyclophosphamide, and rituximab to see which works better in treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
Trials With No Placebo
Virus Therapy
LAIV for Flu
This trial is testing the hypothesis that the T-bet expressing fraction of flu-specific B cells after receiving the live attenuated influenza vaccine (LAIV) serves as an early biomarker of long-lived antibody responses after vaccination.
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Frequently Asked Questions
Introduction to flu
What are the top hospitals conducting flu research?
When it comes to combating the ever-evolving flu virus, several hospitals across the United States are leading the way in clinical trials. In Birmingham, Alabama, the University of Alabama at Birmingham is making strides with three active flu trials and a total of eight conducted since their first recorded trial back in 2005. Meanwhile, in Houston's M D Anderson Cancer Center, researchers are focusing on the intersection between cancer and influenza with three ongoing studies. Although they have only recently started exploring flu trials in 2021, this renowned center is committed to uncovering new insights into this viral infection.
Heading north to Chicago brings us to GSK Investigational Site—an institution dedicated specifically to investigational research—with two active flu trials and five completed studies since its inception in 2008. Further westward lies Meridian Clinical Research, LLC based in Omaha—a facility that has been actively involved with influenza research for quite some time. With two current trials underway and an impressive twelve completed studies dating back to 2004, their contributions have proven invaluable towards understanding and finding effective treatments for the flu virus.
Lastly but not least important on our list is St. Joseph's Hospital and Medical Center located amidst Phoenix's vibrant landscape which like MD Anderson Cancer Centers just entering into conducting these crucial examinations; as recent as2022 where starting off by recording one significant breakthrough after another having already initiated two new experiments already.The dedication exhibited by these top hospitals demonstrates a commitment to tackling one of humanity's most persistent health challenges—the seasonal influenza virus—and ultimately striving toward alleviating its impact worldwide.
Which are the best cities for flu clinical trials?
When it comes to flu clinical trials, several cities emerge as prominent hubs for research. Miami, Florida leads the pack with 23 ongoing trials focusing on a variety of interventions including bivalent BNT162b2 + QIV and Quadrivalent Influenza mRNA Vaccine MRT5407. Columbus, Ohio closely follows with 14 active trials exploring topics such as quality-of-life assessment and BLI5100 High Dose. San Diego, California and Los Angeles, California both have 13 active flu trials each that investigate different treatments like Fluorouracil and Enhanced Text Reminders. Lastly, Phoenix, Arizona boasts 12 active studies examining potential breakthroughs like Quadrivalent influenza modRNA vaccine and Ofatumumab. These cities offer individuals an opportunity to participate in cutting-edge research aimed at improving flu prevention and treatment strategies.
Which are the top treatments for flu being explored in clinical trials?
Researchers are actively investigating various treatments to combat the flu in clinical trials. Among them, three leading contenders have emerged:
- Baloxavir marboxil: Currently being explored in 8 active trials for the flu.
- Favipiravir: Under investigation in 6 ongoing clinical trials targeting influenza.
- Lopinavir/ritonavir: Being evaluated in 4 active studies as a potential treatment option for the flu. These promising candidates offer hope for improved management and prevention of this widespread illness.
What are the most recent clinical trials for flu?
Recent clinical trials have been conducted to explore new treatments and strategies for managing the flu. Phase 4 trial of Group i, which became available on 9/15/2023, holds promise in enhancing our understanding of the virus and its treatment options. Additionally, a Phase 3 trial called Treatment Period 1 (available from 9/5/2023) is investigating potential interventions for flu. Another noteworthy study is SPR720 (Phase 1), which became available on 8/1/2023, offering insights into novel approaches to combatting this contagious respiratory illness. These trials contribute to ongoing efforts aimed at improving prevention measures and developing more effective treatments against the flu.
What flu clinical trials were recently completed?
Several recent clinical trials have made significant strides in the field of flu research, paving the way for improved prevention and treatment options. Among these breakthroughs is a trial conducted by Seqirus, which tested the efficacy of Experimental: aIIV-B Investigational as a single intramuscular dose on Day 1, completing in August 2022. Additionally, Seqirus completed another trial involving aH5N6c on Day 22 in July 2022. Notably, FluGen Inc's Cam2020 M2SR H3N2 influenza vaccine study concluded successfully in June 2022. These trials represent important advancements that contribute to our understanding and management of flu-related illnesses.