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Atypical Antipsychotic

Lurasidone for Depression, Bipolar Disorder

Phase 4
Waitlist Available
Led By Martin Lan, MD PhD
Research Sponsored by New York State Psychiatric Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 15 minutes
Awards & highlights

Summary

The goal of this project is to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, the project focuses on the importance of dopamine signaling in the process. Participants will have two different brain scans (MRI and PET scan). They will also have treatment for your depression with an FDA approved medication, lurasidone (Latuda). The study is funded by the Columbia University Irving Institute to improve the treatment of bipolar disorder.

Eligible Conditions
  • Depression, Bipolar Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~15 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 15 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Montgomery Asberg Depression Rating Scale

Side effects data

From 2016 Phase 4 trial • 35 Patients • NCT02199743
21%
Insomnia
21%
Sedation
14%
Stiffness in jaw
7%
diabetes mellitus
100%
80%
60%
40%
20%
0%
Study treatment Arm
Lurasidone (LUR)
NONLUR

Trial Design

1Treatment groups
Experimental Treatment
Group I: LurasidoneExperimental Treatment1 Intervention
Open-label treatment with lurasidone within the dose range of 20-60 mg daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lurasidone
FDA approved

Find a Location

Who is running the clinical trial?

New York State Psychiatric InstituteLead Sponsor
477 Previous Clinical Trials
154,027 Total Patients Enrolled
Columbia UniversityOTHER
1,471 Previous Clinical Trials
2,536,349 Total Patients Enrolled
Martin Lan, MD PhDPrincipal InvestigatorColumbia University
~0 spots leftby Sep 2025
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