Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
Recruiting in Palo Alto (17 mi)
BD
Overseen byBoris D Heifets, MD, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 4
Waitlist Available
Sponsor: Stanford University
Prior Safety Data
Approved in 5 Jurisdictions
Trial Summary
What is the purpose of this trial?
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery. Half of participants will receive a ketamine infusion during surgery, while the other half will receive a placebo (normal saline) during surgery.
Research Team
BD
Boris D Heifets, MD, PhD
Principal Investigator
Stanford University
Eligibility Criteria
Inclusion Criteria
Patient presenting for primary total joint arthroplasty
You have major depressive disorder.\n
Treatment Details
Interventions
- Ketamine (NMDA Receptor Antagonist)
- Normal saline (placebo) (Other)
Participant Groups
3Treatment groups
Experimental Treatment
Placebo Group
Group I: Open label ketamineExperimental Treatment1 Intervention
Patients will receive an intravenous ketamine infusion during surgery.
Group II: Double blind ketamineExperimental Treatment1 Intervention
Patients will receive an intravenous ketamine infusion during surgery.
Group III: Double blind placeboPlacebo Group1 Intervention
Participants will receive placebo (normal saline infusion) during surgery.
Ketamine is already approved in Canada for the following indications:
Approved in Canada as Spravato for:
- Treatment-resistant depression
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Stanford UniversityStanford, CA
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Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor
Trials
2527
Patients Recruited
17,430,000+