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Thyroid Hormone Replacement

Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism

Phase 4
Waitlist Available
Research Sponsored by Université de Sherbrooke
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
Pivotal Trial
All Individual Drugs Already Approved
Approved for 5 Other Conditions
No Placebo-Only Group
Drug Has Already Been Approved

Summary

The purpose of this study is to determine whether levothyroxine supplementation is beneficial in patients with systolic heart failure and subclinical hypothyroidism on the functional class evaluated with a 6 minute walk test.

Eligible Conditions
  • Heart Failure
  • Hypothyroidism

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Increase in heart rate measurement

Awards & Highlights

Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.

Trial Design

1Treatment groups
Experimental Treatment
Group I: LevothyroxineExperimental Treatment1 Intervention
Levothyroxine supplementation

Find a Location

Who is running the clinical trial?

Université de SherbrookeLead Sponsor
307 Previous Clinical Trials
77,584 Total Patients Enrolled
5 Trials studying Heart Failure
629 Patients Enrolled for Heart Failure
Michel Nguyen, MDStudy DirectorCentre de recherche du Centre hospitalier universitaire de Sherbrooke
1 Previous Clinical Trials
43 Total Patients Enrolled
~4 spots leftby Jan 2026
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