Behavioral Intervention
Cognitive Behavioral Therapy for Serious Mental Illness-related Chronic Pain
This trial is testing whether a therapy called CBT-CP, which is used to help manage chronic pain, is feasible and acceptable to Veterans with SMI, and if it is worth examining in a larger clinical trial.
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Trials for Opioid Use Disorder Patients
Cannabinoid
Medical Cannabis for Chronic Pain
This trial will investigate if medical cannabis can effectively reduce pain and improve quality of life for patients with chronic conditions. The study will gather data through an online questionnaire about patients' use of cannabis and its effects. Medical cannabis interacts with the body's natural system to help manage pain and other symptoms. Medical cannabis has been increasingly studied and used as an alternative treatment for managing chronic pain, with numerous studies supporting its potential benefits.
Non-invasive Brain Stimulation
tDCS + TUS for Opioid Use Disorder
This trial will study whether transcranial Direct Current Stimulation (tDCS) + Transcranial Ultrasound (TUS) can help treat addiction in people with chronic pain who use opiates. The investigators think active stimulation will be better than fake stimulation.
Behavioral Intervention
ACT + MBRP for Chronic Pain and Opioid Abuse
This trial will examine whether an integrated treatment of Acceptance and Commitment Therapy and Mindfulness-Based Relapse Prevention can reduce pain interference and substance misuse in veterans with chronic pain and opioid use disorder, compared to an education control consisting of education sessions on chronic pain, opioids, and buprenorphine use.
N/A
Neurophysiological Assessments for Chronic Pain and Opioid Risk
This trial is studying how well different neurophysiological and behavioral factors can predict pain avoidance in people with chronic pain, and whether this varies between people at different risk levels for opioid addiction.
Trials for OUD Patients
Cannabinoid
Medical Cannabis for Chronic Pain
This trial will investigate if medical cannabis can effectively reduce pain and improve quality of life for patients with chronic conditions. The study will gather data through an online questionnaire about patients' use of cannabis and its effects. Medical cannabis interacts with the body's natural system to help manage pain and other symptoms. Medical cannabis has been increasingly studied and used as an alternative treatment for managing chronic pain, with numerous studies supporting its potential benefits.
Non-invasive Brain Stimulation
tDCS + TUS for Opioid Use Disorder
This trial will study whether transcranial Direct Current Stimulation (tDCS) + Transcranial Ultrasound (TUS) can help treat addiction in people with chronic pain who use opiates. The investigators think active stimulation will be better than fake stimulation.
Behavioral Intervention
ACT + MBRP for Chronic Pain and Opioid Abuse
This trial will examine whether an integrated treatment of Acceptance and Commitment Therapy and Mindfulness-Based Relapse Prevention can reduce pain interference and substance misuse in veterans with chronic pain and opioid use disorder, compared to an education control consisting of education sessions on chronic pain, opioids, and buprenorphine use.
N/A
Neurophysiological Assessments for Chronic Pain and Opioid Risk
This trial is studying how well different neurophysiological and behavioral factors can predict pain avoidance in people with chronic pain, and whether this varies between people at different risk levels for opioid addiction.
Trials With No Placebo
Serotonin-Norepinephrine Reuptake Inhibitor
Duloxetine vs Desipramine for Chronic Pain
This trial aims to compare the effectiveness of two commonly used medications for chronic pain, and to evaluate the feasibility of using an open-source learning healthcare system to monitor patients' progress.
QST for Chronic Pancreatitis
This trial will use a new technique, quantitative sensory testing (QST), to map pain patterns in people with chronic pancreatitis (CP). QST has the potential to improve treatment for CP and may eventually be able to predict response to CP therapies.
Deep Brain Stimulation
DBS for Chronic Pain
This trial is testing a new way to provide deep brain stimulation (DBS) for people with chronic pain that has not been relieved by other treatments. DBS involves surgically placing a small device in the brain that sends electrical signals to specific areas. The goal of this trial is to find out whether DBS is more effective when it is turned on only when needed, rather than continuously.
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Frequently Asked Questions
Introduction to chronic pain
What are the top hospitals conducting chronic pain research?
When it comes to finding relief from chronic pain, several top hospitals across the United States are leading the way in innovative and groundbreaking clinical trials. The University of Michigan in Ann Arbor has emerged as a frontrunner, with four active trials dedicated to chronic pain and a total of 14 completed studies. Their commitment to understanding and treating this debilitating condition began with their first recorded trial in 2011.
Meanwhile, Massachusetts General Hospital in Boston is making significant strides in this field as well. With four ongoing chronic pain trials and eight completed studies under their belt since initiating their first trial in 2008, they have established themselves as an important center for cutting-edge research.
Stanford University in Palo Alto has also joined the ranks of esteemed institutions focusing on chronic pain. Currently conducting three active trials and having conducted seven previous investigations since recording their inaugural trial just two years ago in 2019, they are proving instrumental in advancing our knowledge about effective treatments for this complex condition.
Not far behind them is Indiana University located at Indianapolis, where researchers are currently working on three ongoing chronic pain trials while having contributed to six prior experiments since embarking on their journey into studying this medical issue alongside Stanford University just two years ago again,in2019
Lastly,Vanderbilt University Medical Center situated right at Nashville also happens share similar roles like other counterparts discussed above . They too are involved actively bringing new insights through initiation of three presently functioning clinical tests while contributing towards furthering knowledge through already eighth investigations held; interestingly theirs can be traced backto as recent onlysince two years ago,inthe year 2019.
These notable hospitals represent hope for millions suffering from unrelenting chronic pain by tirelessly exploring potential solutions through rigorous scientific exploration. Their dedication underscores the significance placed on easing suffering and improving quality of life for those affected by this pervasive condition—which affects people regardless of location or age—while ensuring that no stone remains unturned until lasting relief becomes attainable.
Which are the best cities for chronic pain clinical trials?
When it comes to chronic pain clinical trials, several cities in the United States offer promising opportunities for research and treatment. New york City leads with 11 active trials investigating innovative approaches like Pain Coping Skills Training, Pharmacogenetic testing, and Active tdcs. Boston and Nashville follow closely behind with 8 ongoing studies each focused on interventions such as Patients with Implanted Devices on Minimal/No Stimulation Settings, Active Brains 1 MET-based therapy, and cCBT. Indianapolis and Chicago also contribute to advancing chronic pain management through their respective trials exploring topics like pharmacogenetic testing, exercise intervention effects on veterans, stellate ganglion block, and more. These cities serve as hubs of scientific investigation that aim to alleviate the burden of chronic pain for individuals seeking relief and improved quality of life.
Which are the top treatments for chronic pain being explored in clinical trials?
Clinical trials are actively exploring new treatments for chronic pain, aiming to provide relief and improve quality of life for those affected. Two leading contenders in this research include Empowered Relief for Youth and Conventional Medical Management. Both treatments have one active trial dedicated to chronic pain, marking their debut on the clinical scene in 2023. These innovative approaches hold promise for addressing the challenges posed by chronic pain and offer hope to individuals seeking effective solutions.
What are the most recent clinical trials for chronic pain?
Recent clinical trials offer promising insights into the management of chronic pain. One notable study explores the potential benefits of intravenous oxytocin, a hormone known for its role in social bonding. This Phase 2 trial aims to assess oxytocin's efficacy in alleviating chronic pain symptoms and improving patients' quality of life. Another investigation focuses on active stimulation as a treatment approach for chronic pain, with both Phase 1 and Phase 2 studies demonstrating encouraging results. Additionally, research examines the impact of vitamin D2 supplementation on chronic pain, aiming to determine if this intervention can provide relief to individuals suffering from persistent discomfort. These innovative trials underscore ongoing efforts to explore novel strategies for addressing chronic pain more effectively.
What chronic pain clinical trials were recently completed?
Recently, several clinical trials focused on chronic pain have reached important milestones, offering potential breakthroughs for patients seeking relief. Eli Lilly and Company completed two notable trials: one investigating LY3526318 in January 2022 and another studying LY356318 in October 2021. Additionally, a trial sponsored by Novartis Pharmaceuticals explored SAF312 and concluded in April 2021. Winston Parris, MD's study on Bonipar wrapped up in December 2020, while Jacques E. Chelly's investigation into Ketamine was completed back in December 2019. These advancements signal the ongoing commitment of researchers to uncover effective treatments for chronic pain management and offer hope to those affected by this challenging condition.