Angiotensin II for Septic Shock

Recruiting in Palo Alto (17 mi)

Overseen ByAshish Khanna, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: Wake Forest University Health Sciences

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?Despite best therapy efforts, sepsis and septic shock are associated with mortality rates of up to 40%. This clinical trial will determine the benefit of exogenous Angiotensin II versus norepinephrine (conventional care) treatment in septic shock patients. This trial will determine whether there are better predictors of septic shock severity. This approach may inform more appropriate treatment regimens and improve outcomes for these patients.

Eligibility Criteria

This trial is for patients with septic shock, a severe infection causing dangerously low blood pressure. Participants must have confirmed sepsis and require vasopressors to maintain blood pressure. Specific inclusion or exclusion criteria are not provided but typically would involve health status and prior treatments.

Inclusion Criteria

I am currently experiencing severe sepsis with low blood pressure.

I might have or have been diagnosed with an infection.

I need Norepinephrine to keep my blood pressure at 65 mmHg.

Exclusion Criteria

I am expected to undergo urgent surgery soon.

I have had a bone marrow transplant in the last 30 days.

I am under 18 years old.

Participant Groups

The study is testing the effectiveness of Angiotensin II compared to norepinephrine in treating septic shock. It aims to find out if Angiotensin II can better predict the severity of septic shock and improve patient outcomes than the conventional treatment.

2Treatment groups

Experimental Treatment

Active Control

Group I: Angiotensin IIExperimental Treatment1 Intervention

Continuous infusion of Angiotensin II for up to 48 hours

Group II: NorepinephrineActive Control1 Intervention

Continuous infusion of Norepinephrine for up to 48 hours