Alcohol Effects on Drinking Behavior
(CSDP Trial)

Recruiting in Palo Alto (17 mi)

Overseen byAndrea C King, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Chicago

Trial Summary

What is the purpose of this trial?This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by: 1. Examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns. 2. Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews. 3. Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.

Eligibility Criteria

This trial is for adults aged 21-65 who weigh between 110-210 lbs and drink alcohol at least once a week, including weekly 'binge' drinking episodes. They must be reachable for follow-ups for two years and able to attend two sessions at the University of Chicago. People with major medical or psychiatric disorders, or alcohol/substance dependence cannot join.

Inclusion Criteria

I can attend in-person screenings and experimental sessions at the University of Chicago.

I weigh between 110 and 210 lbs.

I can be contacted for follow-ups for at least 2 years after sessions.

+2 more

Exclusion Criteria

You have a history of major medical or psychiatric disorders, including alcohol or substance dependence.

Participant Groups

The study is looking into why young adults might start and keep drinking too much by testing their reactions to alcohol (ethanol) and other substances like Diphenhydramine (an antihistamine) and caffeine compared to a placebo. It also tracks if these responses predict future drinking habits.

6Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Beverage with Low Alcohol DoseExperimental Treatment1 Intervention

Beverage containing 0.4 g/kg alcohol

Group II: Beverage with Heavy Alcohol DoseExperimental Treatment1 Intervention

Beverage containing 0.8 g/kg alcohol

Group III: Beverage with DiphenhydramineExperimental Treatment1 Intervention

Beverage containing 1.5 standard dose of Diphenhydramine (Benadryl)

Group IV: Beverage with CaffeineExperimental Treatment1 Intervention

Beverage containing the equivalent of 1.5 times participant's average caffeine consumption