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Behavioral Intervention
Delayed Word Repetition for Aphasia
N/A
Waitlist Available
Led By Nadine Martin, Ph.D.
Research Sponsored by Temple University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 6 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to improve language abilities in people with aphasia by testing a hypothesis that these abilities are supported by the same cognitive processes.
Who is the study for?
This trial is for right-handed adults aged 21-80 with aphasia due to a single left hemisphere stroke, at least six months post-stroke. Participants must have high school education or higher, English proficiency, good hearing and vision (with aids if needed), and no history of mental illness, neurological disease unrelated to stroke, substance abuse, or inability to consent.
What is being tested?
The study tests a treatment based on the 'activation-maintenance hypothesis' which suggests that verbal short-term memory and word processing impairments in aphasia are linked. The intervention involves repeating words after a time delay to improve language processing and memory in people with aphasia.
What are the potential side effects?
Since the intervention is non-medical involving speech exercises there may be minimal physical side effects; however fatigue or frustration could occur due to the challenges of engaging in repetitive language tasks.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline and 6 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 6 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change from Baseline Verbal Short-Term Memory (STM) Span at 6 weeks
Secondary study objectives
Change in proportion of words retrieved in picture naming
Discourse measures, changes in rates of context information units
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Word repetition after a tiem delayExperimental Treatment1 Intervention
People with Aphasia and Short-Term Memory impairment will receive a behavioral treatment: Word repetition after a time delay. This is the intervention: repetition of words after a 5 or 10 second delay.
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Who is running the clinical trial?
Temple UniversityLead Sponsor
315 Previous Clinical Trials
88,862 Total Patients Enrolled
3 Trials studying Aphasia
422 Patients Enrolled for Aphasia
University of PennsylvaniaOTHER
2,076 Previous Clinical Trials
42,719,695 Total Patients Enrolled
11 Trials studying Aphasia
1,394 Patients Enrolled for Aphasia
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
352 Previous Clinical Trials
181,059 Total Patients Enrolled
38 Trials studying Aphasia
2,391 Patients Enrolled for Aphasia
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a history of mental illness.You can hear sounds at specific frequencies in at least one ear, even with the help of correction like hearing aids.You have had mental health issues in the past.You have a lesion in the left side of your brain.You have had a stroke at least six months ago.You have a history of brain or language problems.You have a history of alcohol or drug abuse.Trouble speaking or understanding language.People with mild difficulty speaking will not be excluded.You can hear well at certain frequencies in at least one ear when tested with a special hearing test.You use your right hand for most tasks.You must be between 21 and 80 years old.
Research Study Groups:
This trial has the following groups:- Group 1: Word repetition after a tiem delay
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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