OBese Patients With Obstructive Sleep Apnea Syndrome(OSAS) and EXercise Training (OBEX1 Trial)
Palo Alto (17 mi)Overseen byJean-Louis Pepin, MD, PhD
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: N/A
Waitlist Available
Sponsor: AGIR à Dom
No Placebo Group
Approved in 1 jurisdiction
Trial Summary
What is the purpose of this trial?The study was designed to test the following hypotheses:
In obese patients with OSAS, the benefit of the combination of exercise training + continuous positive airway pressure (CPAP) will be higher than CPAP alone in term of functional capacity, metabolic, inflammatory, cardiovascular and sleep parameters and quality of life.
In obese patients with OSAS, the benefit of training using ventilatory assistance (NIV) during cycloergometer \[cycloergometer with NIV\] or respiratory muscles training (spirotiger) in addition to cycloergometer \[cycloergometer + spirotiger\] will be higher than cycloergometer training alone \[cycloergometer\] in term of functional and exercise capacities.
Dyspnea during walking test and respiratory muscle strength at baseline could influence the response to combined exercise training such as \[cycloergometer + NIV\] or \[cycloergometer + spirotiger\]
Eligibility Criteria
Treatment Details
2Treatment groups
Active Control
Group I: ERGOActive Control1 Intervention
General endurance training on cycloergometer
Group II: ERGONIV/ ERGOSPIROActive Control1 Intervention
General endurance training on cycloergometer using ventilatory assistance (ERGONIV) or additional respiratory muscle training (ERGOSPIRO)
Find a clinic near you
Research locations nearbySelect from list below to view details:
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)Quebec, Canada
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Who is running the clinical trial?
AGIR à DomLead Sponsor
University Hospital, GrenobleCollaborator