~4 spots leftby Apr 2026

OBese Patients With Obstructive Sleep Apnea Syndrome(OSAS) and EXercise Training

(OBEX1 Trial)

Recruiting in Palo Alto (17 mi)
+1 other location
Overseen byJean-Louis Pepin, MD, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: AGIR à Dom
No Placebo Group
Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

The study was designed to test the following hypotheses: In obese patients with OSAS, the benefit of the combination of exercise training + continuous positive airway pressure (CPAP) will be higher than CPAP alone in term of functional capacity, metabolic, inflammatory, cardiovascular and sleep parameters and quality of life. In obese patients with OSAS, the benefit of training using ventilatory assistance (NIV) during cycloergometer \[cycloergometer with NIV\] or respiratory muscles training (spirotiger) in addition to cycloergometer \[cycloergometer + spirotiger\] will be higher than cycloergometer training alone \[cycloergometer\] in term of functional and exercise capacities. Dyspnea during walking test and respiratory muscle strength at baseline could influence the response to combined exercise training such as \[cycloergometer + NIV\] or \[cycloergometer + spirotiger\]

Eligibility Criteria

Inclusion Criteria

OSAS (AHI > 30 before CPAP treatment)
> 4h/d CPAP treatment adherence
Obese patients with 35 < BMI < 45 kg/m2
See 2 more

Treatment Details

Interventions

  • Exercise Training (N/A)
Participant Groups
2Treatment groups
Active Control
Group I: ERGOActive Control1 Intervention
General endurance training on cycloergometer
Group II: ERGONIV/ ERGOSPIROActive Control1 Intervention
General endurance training on cycloergometer using ventilatory assistance (ERGONIV) or additional respiratory muscle training (ERGOSPIRO)

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ)Quebec, Canada
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Who Is Running the Clinical Trial?

AGIR à DomLead Sponsor
University Hospital, GrenobleCollaborator

References