Dialectical Behavior Therapy for Bipolar Disorder (DB2 Trial)
Recruiting in Palo Alto (17 mi)
Age: < 65
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Centre for Addiction and Mental Health
No Placebo Group
Trial Summary
What is the purpose of this trial?The study intervention is DBT adapted for youth with and/or at familial risk for bipolar disorder. Participants will have completed one full year of DBT in a previous study. This study is examining use of booster sessions. It is delivered in the form of individual sessions and skills sessions, based on the preference of the study participant. The study participant may also receive skills coaching via phone. There is no standard reference therapy/comparator against which the study intervention is being compared.
How is Dialectical Behavior Therapy (DBT) different from other treatments for bipolar disorder?
Dialectical Behavior Therapy (DBT) is unique because it was originally developed for borderline personality disorder and focuses on teaching skills to manage emotions and improve relationships, which may help address mood symptoms in bipolar disorder. Unlike standard treatments that primarily involve medication, DBT offers a structured psychoeducational approach that targets emotional regulation and coping strategies.
24568Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you have Bipolar Disorder Type I, you must be taking at least one mood-stabilizing medication to participate.
Is Dialectical Behavior Therapy (DBT) safe for humans?
DBT has been used safely in various conditions, including borderline personality disorder and alcohol dependency, with studies showing it can reduce harmful behaviors and improve social adjustment without significant safety concerns.
12468What data supports the effectiveness of the treatment Dialectical Behavior Therapy for Bipolar Disorder?
Research suggests that Dialectical Behavior Therapy (DBT) can help improve mood symptoms and emotional control in people with bipolar disorder, similar to its success in treating borderline personality disorder, which also involves mood disturbances.
34578Eligibility Criteria
This trial is for young people aged 14 to nearly 26 who have bipolar disorder or are at risk due to family history. They must have finished a year of DBT in prior studies, be under care by a CAMH psychiatrist, and if they have BD-I, be on mood stabilizers. Participants need to speak English and consent to join.Participant Groups
The study tests 'booster' sessions of Dialectical Behavior Therapy (DBT) tailored for youth with/at risk for bipolar disorder. It includes individual therapy, skills training based on preference, and optional phone coaching. There's no comparison treatment; the focus is on these extra DBT sessions.
1Treatment groups
Experimental Treatment
Group I: Youth with and/or at familial risk for bipolar disorderExperimental Treatment1 Intervention
120 youth aged 14 to 26 with bipolar disorder (type I, type II, not otherwise specified/NOS via KSADS-PL or SCID-5-RV) OR at high-risk for bipolar disorder (parent or sibling with bipolar disorder type I or II via KSADS-PL or SCID-5-RV) will be enrolled in the dialectical behavioral therapy booster session intervention.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
Centre for Addiction and Mental HealthToronto, Canada
Loading ...
Who is running the clinical trial?
Centre for Addiction and Mental HealthLead Sponsor
References
Dialectical behavior therapy for borderline personality disorder: theoretical and empirical foundations. [2022]Dialectical behavior therapy (DBT) is a cognitive-behavioral psychotherapy developed by Linehan for parasuicidal patients with a diagnosis of borderline personality disorder (BPD). DBT is based on a biosocial theory that views BPD as primarily a dysfunction of the emotion regulation system. The treatment is organized around a hierarchy of behavioral goals that vary in different modes of therapy. In two randomized trials, DBT has shown superiority in reducing parasuicide, medical risk of parasuicides, number of hospital days, dropout from treatment and anger while improving social adjustment. Most gains were maintained through a 1-year follow-up. In one process study testing DBT theory, dialectical techniques balancing acceptance and change were more effective than pure change or acceptance techniques in reducing suicidal behavior.
[Application of dialectical behavior therapy as in-patient treatment for alcohol dependency]. [2018]Dialectical behavior therapy (DBT) was originally developed for suicidal female patients with borderline personality disorder (BPD). Meanwhile, DBT-based approaches to psychotherapy have also been successfully applied in other clinical groups. Previous studies of DBT in patients suffering from BPD and comorbid drug addiction are discussed, and an approach to DBT that has been devised by the authors for use in the treatment of alcoholics with comorbid BPD is described. As these patients have more severe clinical problems and less satisfactory treatment responses than do alcoholics without comorbid BPD, we must hope that this new approach will improve clinical outcomes in these severely ill patients.
Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trial. [2018]To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder.
A randomized, controlled, pilot study of dialectical behavior therapy skills in a psychoeducational group for individuals with bipolar disorder. [2018]Bipolar disorder (BD) is a chronic and disabling psychiatric disorder characterized by recurrent episodes of mania/hypomania and depression. Dialectical behavior therapy (DBT) techniques have been shown to effectively treat borderline personality disorder, a condition also marked by prominent affective disturbances. The utility of DBT techniques in treating BD has been largely unexplored. The purpose of this research was to conduct a pilot study of a DBT-based psychoeducational group (BDG) in treating euthymic, depressed, or hypomanic Bipolar I or II patients.
Dialectical behavior therapy for adolescents with bipolar disorder: results from a pilot randomized trial. [2022]The purpose of this study was to conduct a pilot randomized trial of dialectical behavior therapy (DBT) versus psychosocial treatment as usual (TAU) for adolescents diagnosed with bipolar disorder (BP).
Properties of the Dialectical Behavior Therapy Ways of Coping Checklist in a Diagnostically Diverse Partial Hospital Sample. [2019]Dialectical behavior therapy (DBT) was developed for treatment of borderline personality disorder (BPD), and adapted forms of DBT are currently used to treat bipolar disorder, eating disorders, anxiety, and depression. This study was designed to validate the Dialectical Behavior Therapy Ways of Coping Checklist (DBT-WCCL) DBT Skills subscale (DSS) for use in a diagnostically heterogeneous sample.
Effectiveness of Dialectical Behavioral Therapy on Executive Function, Emotional Control and Severity of Symptoms in Patients with Bipolar I Disorder. [2022]Bipolar disorder is a disabling illness characterized by recurrent episodes of mania, hypomania, and depression. The dialectical behaviour therapy (DBT) is basically designed to help regulate excitement, tolerance of discomfort, mindfulness and interpersonal relationships. This study aimed to determine the effectiveness of DBT on executive function, emotional control and symptom relief in patients with type 1 bipolar disorder.
A systematic review on the effectiveness of dialectical behavior therapy for improving mood symptoms in bipolar disorders. [2023]Evidence-based psychotherapies available to treat patients with bipolar disorders (BD) are limited. Dialectical behavior therapy (DBT) may target several common symptoms of BD. We conducted a systematic review on the efficacy of DBT for mood symptoms in patients with BD. The systematic search used key words related to DBT and BD in Medline, Embase, PsycInfo, CINAHL, and Cochrane Library databases from 1980 to April 1st, 2022. We included studies that enrolled patients with a BD I or II diagnosis (DSM or ICD), age 12 and older who received a DBT-based intervention. Studies reviewed were clinical trials including observational studies that reported at least one outcome related to BD mood symptoms or severity. We did not exclude based upon psychiatric or physical co-morbidity.