Exemestane in Reducing Breast Density in Postmenopausal Women at Risk for Breast Cancer

Recruiting in Palo Alto (17 mi)

+11 other locations

Age: Any Age

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: NCIC Clinical Trials Group

Approved in 4 Jurisdictions

Trial Summary

What is the purpose of this trial?

RATIONALE: High estrogen levels may be associated with dense breast tissue and an increased risk of developing breast cancer. Exemestane may be effective in preventing the development of breast cancer by decreasing estrogen levels and reducing breast density. PURPOSE: Randomized clinical trial to study the effectiveness of exemestane in preventing the development of breast cancer by decreasing estrogen levels and reducing breast density in postmenopausal women who are at increased risk for breast cancer.

Research Team

Paul E. Goss, MD, PhD

Principal Investigator

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

Radiologically confirmed density occupying at least 25% of the breast tissue on baseline mammogram*

Grade 2, 3, 4, 5, or 6 (Boyd classification)

Participants with different grades between the 2 breasts should be classified according to a higher grade NOTE: *Performed within 6 months before study entry

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