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MRI Study of Eating Behavior for Bulimia

N/A

Recruiting

Led By Laura A Berner, Ph.D.

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 6-month follow-up

Awards & highlights

No Placebo-Only Group

Summary

This trial wants to understand how bulimia nervosa affects people's decisions about control & eating, to develop better treatments.

Who is the study for?

This trial is for right-handed, English-speaking females aged 18-45 with a BMI between 18.5 and under 30 who meet the criteria for bulimia nervosa. It's not suitable for those medically unstable, on ongoing treatment, doing shift work, pregnant or lactating, allergic to meal ingredients used in the study, or unable to undergo an fMRI.

What is being tested?

The study examines how eating affects decision-making and self-control in women with bulimia nervosa by comparing their brain activity before and after eating using MRI scans while they are in fasting and fed states.

What are the potential side effects?

There may be minimal side effects related to fasting or consuming standardized meals. The MRI procedure might cause discomfort due to its enclosed nature but generally does not have significant side effects.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 6-month follow-up

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 6-month follow-up

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 6-month follow-up for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Secondary study objectives

Binge-eating Severity

Cognitive Effort Discounting Task Behavioral Performance

Compensatory Behavior Severity

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Participants with Bulimia NervosaExperimental Treatment3 Interventions

Participants are randomly assigned (in even numbers across the two groups) to scan order: A. These participants are first scanned after 16 hours of fasting on one day, and are next scanned after a standardized meal on a second day. B. These participants are first scanned after a standardized meal on one day, and are next scanned after 16 hours of fasting on a second day.

Group II: Participants without Bulimia NervosaActive Control3 Interventions

Do I qualify?Apply below to find out