Electroencephalography Guidance of Anesthesia
(ENGAGES Trial)

Recruiting in Palo Alto (17 mi)

Overseen byMichael S. Avidan, MBBCh, FCASA

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Washington University School of Medicine

No Placebo Group

Trial Summary

What is the purpose of this trial?This study aims to determine whether, compared with usual anesthetic care, an electroencephalography-guided anesthesia protocol is effective at preventing postoperative delirium and its downstream effects, and improving postoperative patient reported health-related quality of life.

Eligibility Criteria

Inclusion Criteria

Patients 60 years old and older

Competent to provide informed consent

Undergoing major elective surgery that requires a minimum stay of 2 days postoperatively (e.g., open cardiac surgery, open thoracic surgery, major vascular surgery, intra-abdominal surgery, open gynecologic surgery, open urologic surgery, major orthopedic surgery, open hepato-biliary surgery and major ear, nose and throat surgery)

+3 more

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: EEG guided protocolExperimental Treatment1 Intervention

Participants will have a pragmatic EEG-guided anesthetic protocol during their surgery. Practitioners will modify administration of anesthesia in an attempt to limit the occurrence of EEG burst suppression or persistent suppression.

Group II: Control ArmActive Control1 Intervention

Participants will have the standard anesthetic protocol.