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Electroencephalography Guidance of Anesthesia (ENGAGES Trial)

N/A
Waitlist Available
Led By Michael S. Avidan, MBBCh, FCASA
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
No Placebo-Only Group

Summary

This study aims to determine whether, compared with usual anesthetic care, an electroencephalography-guided anesthesia protocol is effective at preventing postoperative delirium and its downstream effects, and improving postoperative patient reported health-related quality of life.

Eligible Conditions
  • Delirium

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to one year postoperatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to one year postoperatively for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of Participants With Delirium
Secondary study objectives
Health Related Quality of Life
Postoperative Falls
Other study objectives
Agreements Among the FAM-CAM, Researchers' Delirium Assessments and Patient Perceptions
Clinically Relevant Outcomes Associated With Delirium
Collaborations With Other Studies
+10 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: EEG guided protocolExperimental Treatment1 Intervention
Participants will have a pragmatic EEG-guided anesthetic protocol during their surgery. Practitioners will modify administration of anesthesia in an attempt to limit the occurrence of EEG burst suppression or persistent suppression.
Group II: Control ArmActive Control1 Intervention
Participants will have the standard anesthetic protocol.

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
2,000 Previous Clinical Trials
2,342,862 Total Patients Enrolled
8 Trials studying Delirium
75,270 Patients Enrolled for Delirium
National Institute on Aging (NIA)NIH
1,804 Previous Clinical Trials
28,193,499 Total Patients Enrolled
37 Trials studying Delirium
37,847 Patients Enrolled for Delirium
Nan Lin, PhDStudy DirectorWashington University School of Medicine
Susan Stark, PhDStudy DirectorWashington University School of Medicine
5 Previous Clinical Trials
786 Total Patients Enrolled
Troy Wildes, MDStudy DirectorWashington University School of Medicine
3 Previous Clinical Trials
114,616 Total Patients Enrolled
1 Trials studying Delirium
73,952 Patients Enrolled for Delirium
Anke Winter, MDStudy DirectorWashington University School of Medicine
Sharon Inouye, MDStudy DirectorHebrew Rehabilitation Center
Arbi Ben Abdallah, PhDStudy DirectorWashington University School of Medicine
1 Previous Clinical Trials
73,952 Total Patients Enrolled
1 Trials studying Delirium
73,952 Patients Enrolled for Delirium
Michael S. Avidan, MBBCh, FCASAPrincipal InvestigatorWashington University School of Medicine
Eric Lenze, MDStudy DirectorWashington University School of Medicine
9 Previous Clinical Trials
1,947 Total Patients Enrolled
~128 spots leftby Dec 2025
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