Digital Therapeutics for Depression

Recruiting in Palo Alto (17 mi)

+3 other locations

Overseen byLauren Oberlin, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: AdventHealth

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial tests a digital brain training program for older adults with depression-related apathy. The program is expected to improve brain connections and reduce apathy symptoms by enhancing cognitive control.

Eligibility Criteria

This trial is for people over 60 with major depressive disorder and significant apathy, but no psychotic features. They must have a certain level of depression severity, be stable on antidepressants or other psychotropic meds for at least 8 weeks, and not plan to change doses soon. Participants need computer access, can follow instructions in English, are able to undergo MRI scans (no metal implants), and aren't at suicide risk or have serious medical/neurological conditions.

Inclusion Criteria

DRS total score > 129 or DRS scaled score of 5 based on age and education-adjusted normative data

I can sign and understand the consent form for the study.

Montgomery-Åsberg Depression Rating Scale (MADRS) score > or = 16

+9 more

Exclusion Criteria

I have not had electroconvulsive therapy in the last year.

Color Blindness

I am currently in a cognitive rehabilitation program.

+10 more

Participant Groups

The study tests whether a custom digital cognitive training program can improve brain function related to apathy in older adults with depression. Over four weeks, participants will use this program aiming to reduce symptoms of apathy as well as enhance cognitive control performance.

2Treatment groups

Experimental Treatment

Active Control

Group I: Targeted Cognitive Training InterventionExperimental Treatment1 Intervention

Group II: General Cognitive Training InterventionActive Control1 Intervention