TMS for Suicide
Trial Summary
What is the purpose of this trial?
This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive episode (MDE) or borderline personality disorder (BPD).
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, it does exclude participants with certain conditions and devices, so it's best to discuss your specific medications with the trial coordinators.
What data supports the idea that TMS for Suicide is an effective treatment?
The available research shows that TMS for Suicide, specifically using intermittent theta burst stimulation (iTBS), can effectively reduce suicidal thoughts in people with depression. One study found a significant decrease in suicide risk that lasted up to a month, even in those who did not respond to depression treatment. Another study confirmed that iTBS is a safe and effective way to reduce suicidal thoughts in both adults and adolescents with major depressive disorder. These findings suggest that iTBS can be a promising treatment for reducing suicide risk in people with depression.12345
What safety data exists for TMS in treating suicide risk?
The safety of intermittent theta burst stimulation (iTBS) for treating suicide risk has been evaluated in several studies. An accelerated iTBS protocol was found to be safe and well-tolerated in therapy-resistant depressed patients, with no worsening of suicidal ideation observed. Another study confirmed iTBS as a safe treatment for reducing suicidal ideation in adults with major depressive disorder. Additionally, a case series on prolonged iTBS reported some tolerability issues, but overall, iTBS is considered a safe brain stimulation treatment for addressing suicide risk.12356
Is the treatment Intermittent Theta Burst Stimulation (iTBS) a promising treatment for reducing suicide risk?
Eligibility Criteria
This trial is for adults aged 18-60 with major depressive disorder (MDD) or borderline personality disorder (BPD), who are experiencing suicidal thoughts and behaviors. Participants must own a smartphone and be able to use it during their inpatient stay. Those with metal implants, history of seizures, recent substance abuse, or certain psychopathologies like psychosis are not eligible.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Intermittent Theta Burst Transcranial Magnetic Stimulation (Active) (Non-invasive Brain Stimulation)
- Intermittent Theta Burst Transcranial Magnetic Stimulation (Sham) (Non-invasive Brain Stimulation)
Intermittent Theta Burst Transcranial Magnetic Stimulation (Active) is already approved in United States, European Union for the following indications:
- Major Depressive Disorder (MDD)
- Treatment-resistant depression
- Major Depressive Disorder (MDD)
- Treatment-resistant depression