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EEG Markers for ECT Response in Depression
N/A
Waitlist Available
Led By MohammadMehdi Kafashan
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 18 years or greater
Be older than 18 years old
Must not have
Schizophrenia or schizoaffective disorder not being treated for a depressed episode.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 8 weeks during patients ect treatment course
Awards & highlights
No Placebo-Only Group
Summary
This trial looked at whether depression symptoms were linked with changes in brain activity caused by electroconvulsive therapy.
Who is the study for?
This trial is for adults (18+) referred for ECT to treat resistant depression, including major depressive disorder with or without psychotic symptoms, and those with schizophrenia or schizoaffective disorder currently experiencing a depressed episode.
What is being tested?
The study aims to correlate changes in depression symptoms with EEG patterns following electroconvulsive therapy. It involves measuring post-ictal EEG suppression, sleep microstructure, closed loop acoustic stimulation effects, and using the QIDS-SR16 scale.
What are the potential side effects?
While not explicitly listed here, common side effects of ECT may include confusion shortly after treatment, memory loss for events surrounding the period of ECT treatment, physical side effects such as headache, muscle soreness or nausea.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have schizophrenia or schizoaffective disorder and am not currently being treated for depression.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 8 weeks during patients ect treatment course
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 8 weeks during patients ect treatment course
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Electroconvulsive Therapy
Density of EEG sleep spindles during first cycle of non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.
Duration of Central Positive Complexes during ECT treatments.
+4 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Patients with Treatment-Resistant DepressionExperimental Treatment6 Interventions
Find a Location
Who is running the clinical trial?
Washington University School of MedicineLead Sponsor
1,987 Previous Clinical Trials
2,291,548 Total Patients Enrolled
MohammadMehdi KafashanPrincipal Investigator - Washington University School of Medicine
Washington University School of Medicine
1 Previous Clinical Trials
50 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I am referred for ECT due to treatment-resistant depression or a related condition.I have schizophrenia or schizoaffective disorder and am not currently being treated for depression.
Research Study Groups:
This trial has the following groups:- Group 1: Patients with Treatment-Resistant Depression
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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