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EEG Markers for ECT Response in Depression

N/A
Waitlist Available
Led By MohammadMehdi Kafashan
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 years or greater
Be older than 18 years old
Must not have
Schizophrenia or schizoaffective disorder not being treated for a depressed episode.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 8 weeks during patients ect treatment course
Awards & highlights
No Placebo-Only Group

Summary

This trial looked at whether depression symptoms were linked with changes in brain activity caused by electroconvulsive therapy.

Who is the study for?
This trial is for adults (18+) referred for ECT to treat resistant depression, including major depressive disorder with or without psychotic symptoms, and those with schizophrenia or schizoaffective disorder currently experiencing a depressed episode.
What is being tested?
The study aims to correlate changes in depression symptoms with EEG patterns following electroconvulsive therapy. It involves measuring post-ictal EEG suppression, sleep microstructure, closed loop acoustic stimulation effects, and using the QIDS-SR16 scale.
What are the potential side effects?
While not explicitly listed here, common side effects of ECT may include confusion shortly after treatment, memory loss for events surrounding the period of ECT treatment, physical side effects such as headache, muscle soreness or nausea.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have schizophrenia or schizoaffective disorder and am not currently being treated for depression.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 8 weeks during patients ect treatment course
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 8 weeks during patients ect treatment course for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Electroconvulsive Therapy
Density of EEG sleep spindles during first cycle of non-rapid eye movement (NREM) stages N2 on evenings following ECT treatments.
Duration of Central Positive Complexes during ECT treatments.
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with Treatment-Resistant DepressionExperimental Treatment6 Interventions

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,991 Previous Clinical Trials
2,295,853 Total Patients Enrolled
MohammadMehdi KafashanPrincipal Investigator - Washington University School of Medicine
Washington University School of Medicine
1 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

Electroconvulsive Therapy (ECT) Clinical Trial Eligibility Overview. Trial Name: NCT04451135 — N/A
Major Depressive Disorder Research Study Groups: Patients with Treatment-Resistant Depression
Major Depressive Disorder Clinical Trial 2023: Electroconvulsive Therapy (ECT) Highlights & Side Effects. Trial Name: NCT04451135 — N/A
Electroconvulsive Therapy (ECT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04451135 — N/A
~6 spots leftby Nov 2025
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