Exercise Program for Type 2 Diabetes in Older Adults
(RECOVER Trial)

Recruiting in Palo Alto (17 mi)

Overseen byPaul Coen, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Translational Research Institute for Metabolism and Diabetes, Florida

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this research is to gather data on how exercise can help recovery of muscle mass, strength, and physical function after bedrest in older adults with pre-diabetes and type 2 diabetes.

Eligibility Criteria

This trial is for men and women aged 60-80 with pre-diabetes or type 2 diabetes, managed with up to three oral medications and an Hgb A1C < 8.0%. They must have stable cholesterol levels, normal kidney function, be willing to follow the study protocol, and not have had recent major surgery or hospitalization. Exclusions include severe health conditions like active cancer, uncontrolled hypertension, significant heart issues within the last six months, mental impairment (mini-Mental State Examination score < 21), allergies to certain medications including heparin and lidocaine.

Inclusion Criteria

My kidney function is good, with an eGFR over 45.

I have pre-diabetes or type 2 diabetes, take up to 3 diabetes pills, and my Hgb A1C is below 8%.

Participant states willingness to follow protocol as described, the prescribed activity level and completing any forms needed throughout the study.

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Exclusion Criteria

I am not taking any medication that interacts with blood thinners.

My liver function is significantly impaired, or my liver tests are more than 2.5 times the normal limit.

My thyroid is underactive (TSH ≤ 0.5) or overactive (TSH ≥ 10).

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Treatment Details

Interventions

Bed Rest Intervention (Behavioral Intervention)
Exercise Program (Behavioral Intervention)

Trial OverviewThe study investigates how an exercise program can aid muscle recovery after a period of bed rest in older adults with pre-diabetes or type 2 diabetes. Participants will undergo a bed rest intervention followed by prescribed exercises to see if this improves their muscle mass, strength, and physical function.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Non-Exercise RecoveryExperimental Treatment1 Intervention

Older males and females with pre-diabetes or type 2 diabetes. Participants in the ambulatory recovery group will not receive any exercise intervention or advice on exercise following 10 days of bed rest. Rather these participants will return to their regular daily routine that they engaged in prior to the bed rest intervention.

Group II: Exercise RecoveryExperimental Treatment2 Interventions

Older males and females with pre-diabetes or type 2 diabetes. We are examining the effects of a recovery exercise program for older adults with pre-diabetes and type 2 diabetes. Following 10 days of bed rest and during the first 4 weeks of recovery, participants will perform a combination of aerobic and resistance exercise training.