Resveratrol for Coronary Artery Disease
(SIRT-CVS Trial)

Recruiting in Palo Alto (17 mi)

Overseen byMichael Robich, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: MaineHealth

Trial Summary

What is the purpose of this trial?

Major Problem People with diabetes have an increased risk of heart disease, heart failure, and death from a cardiovascular cause. Diabetes prevents efficient metabolism of fuel, causes inflammation and vascular disease that blocks normal blood flow, and inhibits the function of the heart after injury. These changes make diabetics more susceptible to heart attacks and heart failure. Resveratrol is found in grapes and red wine and has been shown to have beneficial effects in diabetic patients. In previous studies the investigators have shown that resveratrol can improve heart metabolism and function in pigs with diabetes and chronic lack of blood flow to the heart. Questions The investigators believe resveratrol will help reverse the negative effects of diabetes on the heart. The questions are: 1.How does the molecular machinery in the hearts of patients with diabetes differ from patients without diabetes? 2.Will resveratrol have an effect on heart metabolism, intracellular signaling, inflammation and blood vessel function? 3.Will resveratrol improve the number and function of cardiac stem cells, cells involved in heart repair? The investigators have been safely collecting tissue from the hearts of patients undergoing heart surgery. Preliminary studies show the investigators can isolate and study cells. The investigators have collected and assessed the function of endothelial cells, a measure of vascular health and can measure the level of endothelial injury and have studied the make-up of caveolae, structures on the cell membrane that are important for cell signaling and are negatively impacted by diabetes. This study is a unique collaboration among cardiologists, cardiac surgeons, and basic scientists.

Eligibility Criteria

Adults over 18 with Type 2 diabetes and coronary artery disease scheduled for elective heart bypass surgery can join. They must not have severe kidney, liver, or blood clotting issues, be pregnant, or have certain infections like HIV. Heavy drinkers and those unlikely to follow the study plan are excluded.

Inclusion Criteria

You are over 18 years old.

You have type 2 diabetes that is managed with pills or insulin.

You have coronary artery disease and are scheduled for elective coronary artery bypass grafting with cardiopulmonary bypass.

Exclusion Criteria

Your blood clotting tests show abnormal results.

Patients who are pregnant

Your liver function tests show results more than two times the normal range.

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Treatment Details

Interventions

Placebo (Behavioural Intervention)
Trans-resveratrol (Polyphenol)

Trial OverviewThe trial is testing if resveratrol (found in grapes/red wine) can improve heart health in diabetics by comparing it against a placebo. It looks at how it affects heart metabolism, inflammation, blood vessel function, and cardiac repair cells.

Participant Groups

2Treatment groups

Experimental Treatment

Placebo Group

Group I: ResveratrolExperimental Treatment1 Intervention

Group II: PlaceboPlacebo Group1 Intervention