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Radiation Therapy

Re-irradiation for Brain Tumor

N/A
Waitlist Available
Led By Douglas Strother, MD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
The patient has a Lansky score of 40% or higher
The patient has a life expectancy anticipated to be at least 8 weeks with treatment using re-irradiation, with or without dexamethasone
Must not have
Females who are pregnant, due to risks from rRT on the developing fetus
Any patient with a condition that prohibits the planned delivery of rRT as prescribed in this study
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to three years from initial diagnosis of dipg
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether re-irradiation can help treat DIPG, a type of brain tumor.

Who is the study for?
This trial is for individuals with a brain tumor called DIPG that's come back or gotten worse. They should be off cancer treatments for 14 days, have no uncontrolled medical issues, and not be pregnant. Participants must agree to avoid other trials, use birth control if needed, and report all medications taken during the study.
What is being tested?
The study tests re-irradiation as a treatment for DIPG after it has progressed or recurred. It's a single-arm trial where everyone gets the same therapy without being compared to another group or receiving a placebo.
What are the potential side effects?
While specific side effects are not listed here, re-irradiation may include risks such as skin irritation at the treatment site, fatigue, headaches, nausea, and potential late effects due to additional radiation exposure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can carry out most of my daily activities on my own.
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My doctor expects me to live at least 8 weeks with my upcoming treatment.
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It has been over 180 days since my last radiation therapy for brain cancer.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am not pregnant, as the treatment could harm a developing fetus.
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I cannot undergo the specific radiation therapy outlined in this study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to three years from initial diagnosis of dipg
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to three years from initial diagnosis of dipg for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
second progression-free survival
Secondary study objectives
overall survival

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients receiving re-irradiationExperimental Treatment1 Intervention
Patients will receive 30.6 Gy or 36 Gy of a second course of radiation therapy for progressive or recurrent DIPG

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
809 Previous Clinical Trials
886,356 Total Patients Enrolled
2 Trials studying Diffuse Intrinsic Pontine Glioma
93 Patients Enrolled for Diffuse Intrinsic Pontine Glioma
Douglas Strother, MDPrincipal InvestigatorUniversity of Calgary
Lucie Lafay-Cousin, MDPrincipal InvestigatorUniversity of Calgary

Media Library

Re-irradiation (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03126266 — N/A
Diffuse Intrinsic Pontine Glioma Research Study Groups: Patients receiving re-irradiation
Diffuse Intrinsic Pontine Glioma Clinical Trial 2023: Re-irradiation Highlights & Side Effects. Trial Name: NCT03126266 — N/A
Re-irradiation (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03126266 — N/A
~0 spots leftby Dec 2024
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