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Exercise for Memory Improvement in Epilepsy

N/A
Recruiting
Led By Jane B. Allendorfer, Ph.D.
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinician-confirmed diagnosis of IGE (including epilepsy syndromes such as juvenile myoclonic epilepsy, juvenile absence epilepsy, childhood absence epilepsy, and generalized tonic-clonic seizures alone)
Males and females aged 18-55 years old
Must not have
Abnormal general or neurological examination
High blood pressure that is not controlled by medications
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6-weeks after baseline
Awards & highlights
No Placebo-Only Group

Summary

This trial tests if an exercise program can improve memory in adults with epilepsy by making their brain work better, especially the part that helps with remembering things.

Who is the study for?
This trial is for English-speaking adults aged 18-55 with Idiopathic generalized epilepsy (IGE) who are relatively healthy, not very active physically, and have had no more than 4 seizure days per month in the past half year. They must be able to undergo MRI scans and cannot be pregnant or involved in another intervention study.
What is being tested?
The study tests a 6-week supervised exercise program's effectiveness on memory improvement in IGE patients compared to those with no intervention. It also examines brain changes due to the exercise and if improvements persist after six weeks post-intervention.
What are the potential side effects?
While specific side effects aren't listed for this type of physical training, participants may experience typical exercise-related discomforts such as muscle soreness, fatigue, or strain injuries.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with a type of generalized epilepsy.
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I am between 18 and 55 years old.
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I've had 4 or fewer days with seizures each month for the last 6 months.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had an abnormal physical or neurological exam.
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My high blood pressure is not managed with medication.
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I have a history of heart or blood vessel problems.
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I've had more than 4 seizure days each month for the last 6 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6-weeks after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6-weeks after baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
estimated interaction effect between exercise group and visit for d'
estimated mediation effect of change in left hippocampus resting state functional connectivity (rsFC) in the effect of exercise on change in d'
Secondary study objectives
estimated interaction effect between exercise group and visit for Learning score
estimated interaction effect between exercise group and visit for Long Delay Free Recall score
estimated interaction effect between exercise group and visit for Montreal Cognitive Assessment (MoCA) score
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Immediate ExerciseExperimental Treatment1 Intervention
immediate participation in 6-week exercise program (intervention)
Group II: Delayed ExerciseExperimental Treatment1 Intervention
6-week delay (no-intervention control) prior to participating in exercise program

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,647 Previous Clinical Trials
2,342,342 Total Patients Enrolled
Jane B. Allendorfer, Ph.D.Principal InvestigatorUniversity of Alabama at Birmingham

Media Library

Delayed supervised combined endurance and resistance training (CERT) Clinical Trial Eligibility Overview. Trial Name: NCT04959019 — N/A
Nonconvulsive Seizures Research Study Groups: Immediate Exercise, Delayed Exercise
Nonconvulsive Seizures Clinical Trial 2023: Delayed supervised combined endurance and resistance training (CERT) Highlights & Side Effects. Trial Name: NCT04959019 — N/A
Delayed supervised combined endurance and resistance training (CERT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04959019 — N/A
~28 spots leftby Dec 2025
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