Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury

Recruiting in Palo Alto (17 mi)

Overseen byPrasad G Iyer, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Mayo Clinic

No Placebo Group

Trial Summary

What is the purpose of this trial?

Is waist to hip ratio (WHR), waist circumference (WC), (as markers of visceral adiposity) associated with an increase in acidic and non acidic reflux as well as systemic inflammation involving esophageal mucosa, thereby increasing esophageal injury and predisposing to subsequent development of Barrett's esophagus (BE)?

Research Team

Prasad G Iyer, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

Subjects over the age of 18 undergoing clinically indicated 24 hour pH impedance and/or pH studies. Many will also undergo clinically indicated endoscopy, and consent for acquiring tissue samples for future biomarker staining tests will be obtained.

Able to give informed consent

Subjects with a prior history of esophageal surgery, or diagnosis of BE

Treatment Details

Interventions

Anthropometry (Behavioural Intervention)
Tissue samples (Procedure)

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Anthropometric Measurements; Tissue SamplesExperimental Treatment2 Interventions

All participants will have their waist circumference and waist to hip ratio taken as a measurement of central obesity. Participants undergoing clinically indicated upper endoscopy and who consent to providing tissue samples will have 8 tissue samples taken for future research purposes.