Magnetogastrogram for Gastroparesis

Recruiting in Palo Alto (17 mi)

Overseen byLeonard A Bradshaw, PhD

Age: Any Age

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Vanderbilt University Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

There is a tremendous clinical need for a noninvasive technique that can assess gastric electrical activity and would be repeatable without any exposure to radiation. Investigators developed a new technique allowing to use noninvasive methods to assess bioelectrical activity in the gastrointestinal system. This has enabled to characterize the normal and pathologic physiology of the stomach through the use of noninvasive magnetogastrogram (MGG) records. Primary hypothesis for this proposal is that analysis of gastric slow wave uncoupling and propagation in multichannel MGG discriminates between normal and pathological gastric electrical activity. Eventually, investigators envision this research leading to new insights for gastrointestinal conditions such as gastroparesis, functional dyspepsia and chronic idiopathic nausea that would inform clinical management of these debilitating diseases.

Research Team

Leonard A Bradshaw, PhD

Principal Investigator

Vanderbilt University Medical Center

Eligibility Criteria

This trial is for people aged 12-80 with conditions like gastroparesis, chronic nausea, or those who've had a gastrectomy. It includes diabetic patients and children with functional dyspepsia. Pregnant women, individuals over 80, those with claustrophobia, morbid obesity, cardiac arrhythmias or on anticoagulants cannot participate.

Inclusion Criteria

I am a child aged 12-17 with stomach upset not caused by any known disease.

I have had all or part of my stomach removed.

I am between 12 and 80 years old.

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Exclusion Criteria

I do not have a history of heart rhythm problems, am not on blood thinners, and am under 80 years old.

You are extremely overweight and may not be able to use the current SQUID devices.

You are afraid of tight spaces and cannot stay still during the test.

See 2 more

Treatment Details

Interventions

Magnetogastrogram (Procedure)

Trial OverviewThe study tests a noninvasive technique called magnetogastrogram (MGG) to assess gastric electrical activity without radiation exposure. The goal is to distinguish normal from abnormal gastric activity which could improve treatment for stomach disorders.

Participant Groups

5Treatment groups

Experimental Treatment

Group I: GastroparesisExperimental Treatment1 Intervention

magnetogastrogram Diabetes with and without gastroparesis ; Idiopathic gastroparesis

Group II: GastrectomyExperimental Treatment1 Intervention

magnetogastrogram Total or partial gastrectomy group

Group III: Functional dyspepsiaExperimental Treatment1 Intervention

magnetogastrogram Children with functional dyspepsia

Group IV: Control participantsExperimental Treatment1 Intervention

magnetogastrogram Group without any gastrointestinal diseases.

Group V: Chronic nauseaExperimental Treatment1 Intervention